Method for detecting reactive intermediate, electrospray ion source apparatus and mass spectrometer

Abstract

The invention discloses a method for detecting reactive intermediate, an electrospray ion source apparatus and a mass spectrometer. The electrospray ion source apparatus comprises a sampling apparatus used for sampling, an electrospray apparatus used for spraying a first part sample in the sampling apparatus in an electrospray manner, and a hook face chemical reactor; and the hook face of the hook face chemical reactor is arranged on a spraying path of the electrospray. By setting the hook face chemical reactor on the spraying path of the electrospray of the electrospray apparatus, the chemical reaction occurs in the ion source, so that the chemical reaction process can be monitored in time and the reaction reactive intermediate with short existence time can be detected; in addition, interference to the chemical reaction from an electrospray high voltage can be avoided, so that the detection of the electrospray mass spectrum can be more accurate, and the actual condition of a to-be-detected system can be better reflected.

Description

technical field [0001] The invention relates to the field of mass spectrometry, in particular to a method capable of detecting active intermediates, an electrospray ion source device and a mass spectrometer. Background technique [0002] Organic chemistry is a discipline that studies the structure, properties and preparation of organic compounds, and is a very important branch of chemistry. The research on the reaction mechanism of organic chemistry can help us better understand the chemical reaction, summarize the rules, and possibly predict whether the chemical reaction will proceed or not and the structure and properties of the product. Therefore, it is an important content of the organic chemistry discipline. In organic chemistry play an important role in development. [0003] The research on the reaction mechanism of organic chemistry mainly includes computational chemistry methods and chemical experiment methods. Computational chemistry methods are based on the princ...

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Problems solved by technology

However, the active intermediates of many chemical reactions exist for a very short time, on the order of milliseconds or even microseconds

However, the injection pipeline of electrospray mass spectrometry is long, and the injection time is generally above the second level, so it is difficult to detect active intermediates with a short existence time.

[0009] In addition, there is a high voltage in the electrospray process, and electrochemical reactions will occur, which may interfere with the system, and many active species in the middle of the reaction may further react in the pipeline, so the test results are difficult to reflect the real system. , which brings great difficulties to the study of the reaction mechanism

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