Preparation method of biodegradable poly(glycolide-epsilon-caprolactone) random copolymer

Abstract

The invention discloses a preparation method of a biodegradable poly(glycolide-epsilon-caprolactone) random copolymer. The method comprises the following steps of mixing glycolide and epsilon-caprolactone at different ratios and adding the mixture to a pressure reaction kettle; adding a catalyst stannous octoate and reacting at certain temperature and stirring speed under a protective gas atmosphere for a period of time; and reducing the temperature to a room temperature, releasing pressure to barometric pressure and terminating reaction to obtain the poly(glycolide-epsilon-caprolactone) random copolymer. Preparation of the poly(glycolide-epsilon-caprolactone) random copolymer is carried out under the protective gas atmosphere in a high-pressure environment, so that the vacuum condition for preparation of a traditional polyester homopolymer or copolymer is avoided, the equipment cost of production is reduced, and large-scale industrial production is facilitated. Ring-opening polymerization under the protective gas atmosphere is more beneficial to heat dissipation of the reaction process than ring-opening polymerization under the vacuum condition and the polymerization is more uniform.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and relates to a preparation method of a biodegradable poly(glycolide-ε-caprolactone) random copolymer. Background technique [0002] Biodegradable polymers such as polylactic acid and its copolymers have been more and more widely used in medical devices and pharmaceutical excipients. In terms of medical devices, surgical sutures, vascular clips, patches, staplers, bone nails, bone plates and other medical device products are currently in a critical period of transition and popularization from non-biodegradable materials to biodegradable polymer materials; In terms of pharmaceutical excipients, drugs for intramuscular and intravenous injection such as drug carrier microspheres and micelles of biodegradable polymer materials are undergoing a large number of clinical trials, and some products have been marketed in many western countries. Medical biodegradable polymer materials are mater...

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Problems solved by technology

Although the above-mentioned patents report the preparation method of the copolymer of ε-caprolactone or glycolide, none of them are the preparation method of the random copolymer of poly(glycolide-ε-caprolactone)

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