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Application of diphenyl ketone compounds in pharmacy

A technology of dibromobenzophenone and dichlorobenzophenone, which is applied in the field of chemical compounds, can solve the problems of recurrence of side effects and achieve significant pharmacological activity

Active Publication Date: 2017-08-04
SHANXI MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, the treatment of chronic nephritis usually adopts classic hormone and immunosuppressant therapy. Although it has a certain effect, it is difficult to fundamentally prevent the development of chronic nephritis due to the serious side effects and recurrence.

Method used

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  • Application of diphenyl ketone compounds in pharmacy
  • Application of diphenyl ketone compounds in pharmacy
  • Application of diphenyl ketone compounds in pharmacy

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Embodiment Construction

[0017] Compounds 4,5,2'-trihydroxy-2,5'-dibromobenzophenone and 4,5,2'-tris(4-morpholinoyloxy)-2,5'-dichlorobis Application of benzophenone in preparation of medicine for treating acute pyelonephritis and chronic nephritis.

[0018] Two drugs for the treatment of acute pyelonephritis and chronic nephritis, the active ingredients of which are the compounds 4,5,2'-trihydroxy-2,5'-dibromobenzophenone and 4,5,2'-tri(4-mol phenoyloxy)-2,5'-dichlorobenzophenone. The drug also includes common pharmaceutical carriers or excipients used in combination with the active ingredients. The medicine can be made into common preparations such as solid dispersion, tablet, drop pill, capsule or injection according to specific requirements.

[0019] Compounds of the present invention 4,5,2'-trihydroxy-2,5'-dibromobenzophenone and 4,5,2'-tris(4-morpholinoyloxy)-2,5'-di The pharmacological effects of chlorobenzophenone in the treatment of acute pyelonephritis and chronic nephritis will be describ...

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Abstract

The invention discloses a novel medical application of two diphenyl ketone compounds 4,5,2'-trihydroxyl-2,5'-dibromo diphenyl ketone and 4,5,2'-tri(4-morpholine methanoyl)-2,5'-dichloro diphenyl ketone, and in particular discloses an application in preparing drugs for treating acute pyelonephritis and chronic nephritis. Meanwhile, the invention also discloses a drug, taking the two compounds as active ingredients, for treating acute pyelonephritis and chronic nephritis. Both the two compounds can effectively improve the renal functions of an acute pyelonephritis model mouse and a chronic nephritis model mouse, remarkably inhibit IL-1alpha, IL-1beta and IL-6 and reduce the inflammatory reactions, thereby showing an important application prospect in treating acute pyelonephritis and chronic nephritis.

Description

technical field [0001] The present invention belongs to the field of new application of compounds, and relates to two compounds capable of preventing and treating acute pyelonephritis and chronic nephritis, specifically compounds 4,5,2'-trihydroxy-2,5'-dibromobenzophenone and 4 , Application of 5,2'-tris(4-morpholinoyloxy)-2,5'-dichlorobenzophenone in the preparation of medicines for preventing and treating acute pyelonephritis and chronic nephritis. Background technique [0002] Acute pyelonephritis is mainly an inflammatory disease of renal tubules, renal interstitium, and renal parenchyma caused by the invasion of various pathogenic bacteria, and the glomerular parts are generally less damaged. If the treatment is not timely, it can turn from acute to chronic, and finally develop into renal failure. The pathogenesis of acute pyelonephritis mainly involves the pathogenicity of bacteria, inflammation and immune response, and the latter two have been paid more and more atte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5377A61K31/12A61P13/12
CPCA61K31/12A61K31/5377A61K2300/00
Inventor 李青山冯秀娥张圆琳韩玲革常熔熔
Owner SHANXI MEDICAL UNIV