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Medical application of cycloastragenol

A cycloastragenol and application technology, which is applied in the direction of medical formula, medical preparations containing active ingredients, drug combinations, etc., can solve the problem of no antiarrhythmic biological activity or clinical application of cycloastragenol, and prolong animal survival time, reduction in the incidence of ventricular fibrillation, and significant therapeutic effect

Inactive Publication Date: 2017-08-04
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no research on the antiarrhythmic biological activity or clinical application of cycloastragenol

Method used

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  • Medical application of cycloastragenol
  • Medical application of cycloastragenol
  • Medical application of cycloastragenol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 cycloastragenol injection

[0021]

[0022] Preparation process: mix the prescribed amount of propylene glycol and ethanol evenly, add cycloastragenol, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% activated carbon for needles, stir, and decarbonize to obtain the product.

Embodiment 2

[0023] Example 2 cycloastragenol injection

[0024]

[0025] Preparation process: Add cycloastragenol to the prescription amount of PEG-400, stir to dissolve, add 0.9% sodium chloride solution to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

Embodiment 3

[0026] Example 3 cycloastragenol injection

[0027]

[0028]

[0029] Preparation process: Mix the prescribed amount of ethanol and Tween-80 evenly, add cycloastragenol, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

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PUM

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Abstract

The invention claims the use of cycloastragenol for preparing drugs for preventing or treating arrhythmia, which belongs to the field of medicine. The cycloastragenol of the present invention is a traditional Chinese medicine monomer extracted from traditional Chinese medicines. Animal experiments have shown that it has a significant preventive effect on arrhythmia, can significantly prolong the appearance time of aconitine-induced arrhythmia in rats, and reduce the risk of ventricular arrhythmia. The duration of fibrillation can reduce the incidence of ventricular fibrillation; significantly prolong the occurrence time of arrhythmia in guinea pigs with arrhythmia induced by ouabain, and prolong the survival time of animals. Cycloastragenol has definite antiarrhythmic effect, low side effects, and broad medical application prospects.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the medical use of cycloastragenol, in particular to the medical use of cycloastragenol in the preparation of drugs for preventing or treating arrhythmia. Background technique [0002] Cardiac arrhythmia is a common and frequently-occurring disease in the field of cardiovascular diseases, and its mechanism can be summarized as abnormal impulse formation, abnormal conduction, or both abnormal impulse formation and conduction. Cardiac arrhythmia is one of the most serious diseases among cardiovascular system diseases. The danger of arrhythmia is that it can not only aggravate the original heart disease, such as accelerating the progress of heart failure, but also lead to sudden death of the patient, which seriously threatens human health. Ischemic heart disease is the main cause of malignant arrhythmias such as ventricular tachycardia and ventricular fibrillation; heart failure is also an im...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P9/06
CPCA61K31/58
Inventor 张贵民李会恩姚景春
Owner LUNAN PHARMA GROUP CORPORATION