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Applications of loganetin in preparation of drugs for prevention or treatment of arrhythmia

A technology of loganin and arrhythmia, which is applied in the field of medicine, can solve the problems of anti-arrhythmia biological activity or clinical application research of loganin, and improve the therapeutic effect and quality of life, with low toxicity and side effects of human body, The effect of reducing the number of animal deaths

Active Publication Date: 2017-07-14
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] So far, there is no research on the antiarrhythmic biological activity or clinical application of loganinin

Method used

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  • Applications of loganetin in preparation of drugs for prevention or treatment of arrhythmia
  • Applications of loganetin in preparation of drugs for prevention or treatment of arrhythmia
  • Applications of loganetin in preparation of drugs for prevention or treatment of arrhythmia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 loganin tablet

[0021]

[0022] Preparation process: Mix loganin, microcrystalline cellulose and sodium carboxymethyl starch evenly, add appropriate amount of starch slurry to make soft material, and pass through a 16-mesh sieve to granulate. The wet granules are dried at 60°C, the dry granules are passed through a 20-mesh sieve for granulation, the fine powder in the dry granules is screened out, mixed with magnesium stearate, and then mixed with the dry granules, pressed into tablets, each tablet is about 200mg, that is, .

Embodiment 2

[0023] Embodiment 2 loganin tablet

[0024]

[0025] Preparation process: mix the loganin starch and dextrin in the prescribed amount evenly. In addition, add an appropriate amount of 50% ethanol to the mixed powder, mix evenly, make soft material, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of the dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 3

[0026] Embodiment 3 loganin capsules

[0027] Loganin 10g

[0028] Microcrystalline Cellulose 300g

[0029] Micronized silica gel 12g

[0030] Preparation process: pulverize loganin, microcrystalline cellulose, and micropowder silica gel, pass through a 100-mesh sieve, mix well, and directly fill capsules.

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Abstract

The present invention relates to uses of loganetin in preparation of drugs for prevention or treatment of arrhythmia, and belongs to the field of medicine. According to the present invention, the loganetin is the tradition Chinese medicine monomer extracted from the traditional Chinese medicine; the animal test results show that the loganetin can significantly prevent and treat arrhythmia, can significantly delay the occurrence of premature ventricualr contraction, ventricular tachycardia and ventricular fibrillation of arrhythmia rats due to aconitine, can significantly reduce the animal mortality, and can significantly inhibit the ventricular fibrillation incidence rate of chloroform-induced arrhythmia mice; and the loganetin has advantages of exact arrhythmia treatment effect, low side effect, and broad medical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a medical application of loganin, in particular to the medical application of loganin in the preparation of drugs for preventing or treating arrhythmia. Background technique [0002] Cardiac arrhythmia is a common and frequently-occurring disease in the field of cardiovascular diseases, and its mechanism can be summarized as abnormal impulse formation, abnormal conduction, or both abnormal impulse formation and conduction. Cardiac arrhythmia is one of the most serious diseases among cardiovascular system diseases. The danger of arrhythmia is that it can not only aggravate the original heart disease, such as accelerating the progress of heart failure, but also lead to sudden death of the patient, which seriously threatens human health. Ischemic heart disease is the main cause of malignant arrhythmias such as ventricular tachycardia and ventricular fibrillation; heart failure is also an impor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P9/06
Inventor 张贵民牟丽丽李会恩张晓敏赵云
Owner LUNAN PHARMA GROUP CORPORATION
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