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A kind of wolfberry polysaccharide granules and preparation method thereof
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A technology of Lycium barbarum polysaccharides and granules, which is applied in the direction of anti-toxic agents, medical formulas, medical preparations of non-active ingredients, etc., can solve the problems of unfavorable research and development of Chinese medicine preparations of Lycium barbarum polysaccharides, high viscosity of Lycium barbarum polysaccharides, complicated granulation process, etc., and achieve good results. Application prospect, improvement of hygroscopicity, effect of simple equipment
Active Publication Date: 2020-01-24
INFINITUS (CHINA) CO LTD
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Problems solved by technology
Due to the high viscosity of Lycium barbarum polysaccharide, it is often accompanied by sticky walls, sticky pulp, and particle agglomeration after making soft materials, and there is a risk of contamination during the transfer of wet granules to drying equipment, and the granulation process is complicated. Therefore, this method was adopted Method granulation is not conducive to the research and development of traditional Chinese medicine preparations of Lycium barbarum polysaccharides, and does not meet the needs of new pharmaceutical preparations
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Embodiment 1
[0031] (1) Preparation of Lycium barbarum polysaccharide
[0032] Lycium barbarum was dried in a thermostat at 60°C for 24 hours, cooled to room temperature and constant weight, crushed, distilled water was added to adjust the material-liquid ratio to 1:10, the temperature was controlled at 80°C, the extraction time was 2h, the supernatant was centrifuged and filtered, and the extraction was repeated twice. Combine the filtrate, concentrate the extract under reduced pressure to 1.5 times the volume of the material, add 3 times the volume of absolute ethanol, stand for 12h at 4°C, filter and collect the filter residue, reconstitute in distilled water, extract twice with alcohol, and wash the filter residue repeatedly with absolute ethanol To nearly colorless, dissolve in distilled water, freeze-dried in vacuum to obtain Lycium barbarum polysaccharide powder. The purity of polysaccharide is 40% by sulfuric acid phenol method;
[0033] (2) Surface modification of wolfberry polysacchar...
Embodiment 2
[0040] (1) Preparation of Lycium barbarum polysaccharide
[0041] Lycium barbarum was dried in a constant temperature oven at 60℃ for 24 hours, cooled to room temperature and constant weight, crushed, distilled water was added to adjust the material-liquid ratio to 1:20, the temperature was controlled at 70℃, the extraction time was 4h, the supernatant was centrifuged and filtered, and the extraction was repeated twice. Combine the filtrate, concentrate the extract under reduced pressure to 1.5 times the volume of the material, add 3 times the volume of absolute ethanol, stand for 12h at 4°C, filter and collect the filter residue, reconstitute in distilled water, extract twice with alcohol, and wash the filter residue repeatedly with absolute ethanol To nearly colorless, dissolve in distilled water, freeze-dried in vacuum to obtain Lycium barbarum polysaccharide powder. The purity of polysaccharide is 30% by sulfuric acid phenol method;
[0042] (2) Surface modification of wolfberr...
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Abstract
The invention relates to the field of Chinese medicine preparations, in particular to lycium barbarum polysaccharide granules and a preparation method thereof. The preparation method comprises, by weight, 20-40 parts of lycium barbarum polysaccharide powder, 20-40 parts of lactose, 5-20 parts of dextrin, 5-20 parts of microcrystalline cellulose and 1-10 parts of silicon dioxide. The lycium barbarum polysaccharide granules adopt specific surface modification auxiliary materials, the hygroscopicity, liquidity and dispersion of the polysaccharide powder is effectively improved, and the lycium barbarum polysaccharide granules are high in forming rate and are conductive to follow-up research and development of Chinese medicine preparations. The invention further provides the preparation method of the granules. Required devices are simple, a production period is short, the production cost is remarkably reduced, the production efficiency is improved, and the lycium barbarum polysaccharide granules are suitable for large-scale production and usage and have a good application prospect.
Description
Technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a wolfberry polysaccharide granule and a preparation method thereof. Background technique [0002] Fructus Lycii (Fructus Lycii) is the dried and mature fruit of Lycium barbarum L., a plant of the Solanaceae family, and is a traditional precious Chinese medicine. Lycium barbarum polysaccharide is a mixture of glycoproteins, acidic heteropolysaccharides, neutral heteropolysaccharides and other polysaccharides. It has the functions of regulating immunity, scavenging free radicals, anti-aging, anti-fatigue, anti-stress, anti-tumor, protecting liver, lowering blood sugar, A variety of physiological health care and pharmacologically active functions such as lowering blood lipids have great development and utilization value and market prospects. At present, Lycium barbarum polysaccharides are mainly used in medicine and health products, such as Lycium barbarum polys...
Claims
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Application Information
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