Traditional Chinese medicine prescription granule preparation by melted extrusion method

Abstract

The invention relates to a melted extrusion method for preparing traditional Chinese medicine prescription granules, comprising the following steps: using an auxiliary material with a low melting point as a binding agent and evenly mixing with traditional Chinese medicine extract powder according to a certain ratio; placing the mixture in an extrusion pelletiser to prepare into granules in the extrusion process; straightening granules after cooling to obtain the traditional Chinese medicine prescription granules, wherein 40-70 DEG C is preferably used as the melting point or melting range of the low melting point auxiliary material; and the dosage ratio of the auxiliary material accounts for 10-40% of the total weight of the auxiliary material to the traditional Chinese medicine extract powder. The invention has higher molding efficiency, avoids the phenomena such as change of medicine tincture and active ingredients caused by repeated extrusion, weakened dissolubility and the like, thus especially being suitable for traditional Chinese medicine extract powder with poor viscosity and varieties such as fruit and seeds containing high fatty oil and starch, roots and tubers, parts offlowers and plants, leather and the like. The granules prepared by the invention have fine mobility, compressibility and dissolubility, and the granules prepared by using hydrophobic auxiliary materials have lower hygroscopicity.

Description

(1) Technical field [0001] The invention relates to a method for preparing traditional Chinese medicine formula granules, in particular to a melt extrusion method for preparing traditional Chinese medicine formula granules. It is suitable for traditional Chinese medicine varieties with poor viscosity of extract powder, including fatty oil, fruit seeds and rhizomes with high starch content, and some flowers, grasses and bark, etc. It belongs to the technical field of traditional Chinese medicine oral preparations. (2) Background technology [0002] Traditional Chinese medicine formula granules are traditional Chinese medicine granules made from traditional Chinese medicine decoction pieces by extraction, decompression concentration, drying and other methods. It can not only be used by clinicians to formulate prescriptions flexibly, but also can be used as raw materials for the production of traditional Chinese medicine preparations such as Chinese patent medicines. [0003]...

AI Technical Summary

Problems solved by technology

[0005] (1) For the traditional Chinese medicine extract powder with strong hygroscopicity, wet granulation technology is used to prepare granules. The granules are prone to sticking, strip-shaped soft materials, sticking nets, etc., and the produced granules are too hard and poor in solubility, resulting in unstable quality;

[0006] (2) Drug powders containing moisture-sensitive ingredients are prone to degradation when exposed to water, and are not suitable for wet granulation;

[0007] (3) The process route is complicated, the energy consumption is high, and water or other organic solvents are often added in the granulation process, which requires heating and drying, and the production cycle is long

The dry granulation process has a short production cycle and high production efficiency. For traditional Chinese medicine varieties with poor viscosity of extract powder, including fatty oil, fruit seeds and rhizomes with high starch content, and some flowers, grasses and skins, etc. In the process of dry granulation, the granules have a low molding rate at one time, and need to be repeatedly extruded under high pressure, so the production efficiency is very low, and the color of the drug or the active ingredient changes due to repeated extrusion, and the solubility becomes poor.