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Convenient-type transdermal administration patch apparatus and preparation method thereof

A transdermal drug delivery, convenient technology, applied in the direction of drug devices, drug devices, pharmaceutical formulations, etc., can solve the problems of large volume, inconvenient use for patients, skin epidermal damage, etc., to achieve no skin damage, increase drug Effects of species and bioavailability, convenience of administration

Active Publication Date: 2017-08-11
CHANGZHOU HUAJIA MEDICAL DEVICE LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current chemical methods will cause damage to the skin epidermis
Although current physical methods such as iontophoresis and ultrasound are effective, they are inconvenient for patients to use at home due to the large size of the equipment

Method used

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  • Convenient-type transdermal administration patch apparatus and preparation method thereof
  • Convenient-type transdermal administration patch apparatus and preparation method thereof
  • Convenient-type transdermal administration patch apparatus and preparation method thereof

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Experimental program
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Effect test

preparation example Construction

[0034] A preparation method of a portable transdermal drug delivery patch device, including preparation of a drug-containing patch, preparation of a drug-free patch, electrode installation, docking with a microcontroller b, docking with a communication control system, and delivery The drug initiation step is completed to complete the preparation of the portable transdermal drug delivery patch device; the specific steps are as follows:

[0035] (1) Preparation of drug-containing patch: the prepared drug-containing aqueous solution is injected into the middle part of the medical sand cotton, and the 0.2mm part around the sand cotton is attached to the medical tape, and the middle part of the sand cotton is attached to the protective paper On the top, the preparation of the drug-containing patch is completed;

[0036] (2) Preparation of drug-free patch: inject drug-free water or emulsion, gel, lipid, and microspheres into the middle part of the medical sand cotton, and stick the ...

Embodiment 1

[0046] Simulation experiment of porcine skin membrane transdermal administration in vitro:

[0047] (1) Choose a thickness of 300-500μm and an area of ​​1.0cm 2 The pigskin is placed between the supply cell of the Franz diffusion cell and the receiving cell of the Franz diffusion cell. The inner side of the pig skin membrane is facing the supply pool. The pool is filled with phosphate buffered saline to simulate blood circulation, and the temperature in the receiving pool is kept at 37°C to simulate human body temperature.

[0048] (2) Set the power: 0.1mA, and the power-on time is 24 hours according to the needs. Press the instrument power switch.

[0049] (3) After 24 hours, take a sample from the receiving pool, conduct drug analysis with a high-pressure liquid phase analyzer, and record.

[0050] Table 1 below shows the comparison information table between the analysis record of the antiemetic drug otansetron hydrochloride and the traditional patch transdermal delivery ...

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Abstract

The invention discloses a convenient-type transdermal administration patch apparatus and a preparation method thereof. The patch apparatus comprises two units, a communications control device and an administration device, the administration device is fixedly arranged on the lower end section of the communications control device, the communications control device and the administration device make an electrical connection, the communications control device comprises mini cells and a wireless control device and a microcontroller a, the mini cells, the wireless control device and the micro-controller a make electrical connections; after the starting procedures of preparation of drug involved patches, preparation of non-drug involved patches, electrode fixing, docking with a microcontroller b, docking with the communications control system and dosing, the preparation of the convenient-type transdermal administration patch apparatus is fulfilled. The transdermal administration apparatus is wearable and remote-controllable, the dose administration is convenient, and is particularly suitable for the conditions of daily medications for elderly patient with chronic illness and plenty of admitted inpatients: the dose time and amount are pre-arranged by the nursing crew according to the prescription requirements of the doctors, patient medication at fixed time and fixed amount is complied with, and the time and energy of the medical staff are saved.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and in particular relates to a convenient transdermal drug delivery patch device and a preparation method thereof. Background technique [0002] Most drugs are currently administered orally or by injection. Oral administration is in the form of tablets, capsules, liquids, etc. However, due to the absorption of the drug in the gastrointestinal tract and the first-pass effect in the liver, many oral drugs reduce the bioavailability of the drug before reaching the site of action, and often bring come side effects. There are also some drugs that cannot be administered orally, such as: peptides and protein-related drugs. Another common mode of administration is injection, which enables drugs to penetrate biological barriers, including subcutaneous injections and intravenous injections. Although this method is fast and effective, the injection can cause additional pain for the patient, cau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61M37/00A61M2207/00A61M2037/0007A61K9/7084A61M2205/3584A61F13/0283A61F2013/0296A61M35/10A61M2205/3592A61N1/303A61K9/06A61K9/127A61K31/4178A61K31/554A61K47/12A61K47/36A61K47/38A61M2205/50A61M2205/8206
Inventor 胡隆胜朱晶
Owner CHANGZHOU HUAJIA MEDICAL DEVICE LTD
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