Application of calycosin in the preparation of anti-rotavirus drugs

A technology of calycosin and rotavirus, which is applied in the field of medicine, can solve the problems of limited prevention range of RV strain diversity, expensive RV vaccine, and no specific drug for preventing and treating RV infection, so as to prevent and treat rotavirus infection, The effect of good guiding value

Active Publication Date: 2021-02-09
GUANGDONG MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Rotavirus (RV) is the main pathogen that causes acute diarrhea in infants and young children. About 600,000 infants and young children die from RV infection every year. Currently, there is no specific drug for preventing and treating RV infection.
As for the RV vaccine, it is still in the research stage in China, and the RV vaccine marketed abroad is expensive, and the diversity of RV strains makes the scope of prevention limited.

Method used

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  • Application of calycosin in the preparation of anti-rotavirus drugs
  • Application of calycosin in the preparation of anti-rotavirus drugs

Examples

Experimental program
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Effect test

Embodiment 1

[0015] Application of calycosin in the preparation of anti-rotavirus drugs.

[0016] The application of the actcocosin in the preparation of the anti-rotavirus drug reveals that the actcocosin can be used in the preparation of the anti-rotavirus drug, and the application can provide significant value for the development of safe and effective drugs for the prevention and treatment of rotavirus infection.

[0017] Moreover, the application of calycocosin in the preparation of anti-rotavirus drugs in this embodiment reveals that in the anti-rotavirus drugs, the molar concentration of calycocosin in the anti-rotavirus is 10 μmol / L-80 μmol / L, that is, reveals It is found that at a certain drug concentration, calycocoside can prevent and treat rotavirus infection well, and it is revealed that among anti-rotavirus drugs, the molar concentration of calycocoside isoflavone that can produce toxicity to cells is greater than 80 μmol / L. Antirotavirus drugs provide a good guide value.

[...

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Abstract

The invention relates to the technical field of medicine, in particular to the application of calycosin in the preparation of anti-rotavirus drugs. The application of calycosin in the preparation of anti-rotavirus drugs reveals that calycosin can be used in the preparation of anti-rotavirus drugs, and this application can provide significant value for the development of safe and effective drugs to prevent and treat rotavirus infection. And, the application of this actcocosin in the preparation of anti-rotavirus drugs reveals that in the anti-rotavirus drugs, the molar concentration of actcocosin isoflavones against rotavirus is 10umol / L~80umol / L, that is, reveals that in At a certain drug concentration, calycosin can prevent and treat rotavirus infection well, and it reveals that among anti-rotavirus drugs, the molar concentration of calycocosin that can produce toxicity to cells is greater than 80 umol / L, which in turn has a negative effect on the use of calycocosin to resist rotavirus infection. Rotavirus drugs provide a good guide value.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of calycosin in the preparation of anti-rotavirus drugs. Background technique [0002] Rotavirus (RV) is the main pathogen that causes acute diarrhea in infants and young children. About 600,000 infants and young children die from RV infection every year. Currently, there is no effective drug to prevent and treat RV infection. As for the RV vaccine, it is still in the research stage in China, and the RV vaccine listed abroad is expensive, and the diversity of RV strains makes the scope of prevention limited. Oral rehydration solution recommended by WHO is often used clinically to relieve symptoms. Therefore, it is very important to strengthen the research on the mechanism of rotavirus infection and develop safe and effective drugs to prevent and treat rotavirus infection. Contents of the invention [0003] The purpose of the present invention is to provide th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P31/14
CPCA61K31/352
Inventor 赵文昌宋丽军
Owner GUANGDONG MEDICAL UNIV
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