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Nutritional composition for use in promoting gut and/or liver maturation and/or repair

A nutritional composition and composition technology, applied in the direction of food science, etc., can solve the problems of delayed gastric emptying, hindering the continuous delivery of enteral nutrition, accumulation of boluses, etc., and achieve a good stimulating effect

Inactive Publication Date: 2017-08-18
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Immature gastrointestinal motility results in slow transit and delayed gastric emptying, which leads to the accumulation of boluses in the stomach (ie, gastric remnants) and prevents continued delivery of enteral nutrition

Method used

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  • Nutritional composition for use in promoting gut and/or liver maturation and/or repair
  • Nutritional composition for use in promoting gut and/or liver maturation and/or repair
  • Nutritional composition for use in promoting gut and/or liver maturation and/or repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0200] We designed a crossover study in which each subject received all test meals. Subjects were randomly assigned to one of 10 possible random orders for the 5 test products. Each subject received 5 study products during 5 different visits separated by a washout period of at least 1 week and up to 4 weeks. Each follow-up visit lasts for two days (Day 1 (D1) and Day 0 (D0)):

[0201] Day 1: Intake of a standard meal

[0202] ·Day 0:

[0203] - Baseline plasma sample

[0204] - Study product intake

[0205] - plasma samples - breath samples

[0206] Subjects are healthy men aged 20 to 40 with a BMI of 19 to 24.9 kg m -2 , normal fasting blood sugar.

[0207] research description

[0208] The five study products contained the same amount of maltodextrin and whey protein, but differed in their fatty acid composition. All study products accounted for one-third of each subject's daily energy requirements, as measured by physical activity calculated from the Harris Bened...

Embodiment 2A

[0260] Table 8: Examples of lipid blends according to the invention

[0261]

[0262]

Embodiment 2B

[0264] Table 9: Examples of lipid blends according to the invention

[0265] Element Variant 2: Without Betapol-55 MCT oil - Palm Olein - creamy 15.00 Betapol-55 0.00 coconut oil 20.00 canola oil 22.87 sunflower oil 18.28 High Oleic Sunflower Oil 21.59 ARASCO / DHASCO1:1 1.00 ARASCO / DHASCO2:1 1.25 Palmitic acid (% of total fat) 7.80 Palmitic acid sn-2 (% of palmitic acid) 20.30 Palmitic acid sn-1,3 (% of palmitic acid) 79.70 Palmitic acid sn-2 (% of total fat) 1.60 Palmitic acid sn-1,3 (% of total fat) 6.20

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PUM

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Abstract

The present invention relates to synthetic nutritional compositions for use to promote the maturation and / or repair of the liver and / or gut, and / or to treat and / or prevent and / or reduce the risk of liver and / or gut and / or metabolic disease. The compositions according to the invention have low MCT medium chain fatty acid (MCFA) content and low palmitic acid content.

Description

technical field [0001] The present invention relates to a synthetic nutritional composition for promoting the maturation and / or repair of the liver and / or the intestinal tract and / or treating and / or preventing and / or reducing the risk of metabolic diseases of the liver and / or the intestinal tract. The composition according to the invention has a low medium chain fatty acid (MCFA) content and a low palmitic acid content. Background technique [0002] Adequate nutrition is required for recovery from illness, but critically ill patients may develop feeding intolerance. Healthcare providers often interrupt enteral feedings and rely on parenteral feedings to provide patients with essential nutrients. [0003] However, parenteral nutrition is not without its drawbacks. It increases the risk of vein-related infections, sepsis, liver disease, and other concomitant conditions. [0004] Feeding intolerance may also occur in vulnerable infants and / or young children, such as low birt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/12A23L33/00
CPCA23L33/30A23L33/40A23L33/115A23L33/12A23V2002/00
Inventor S·塔卡尔C·L·加尔奇亚-罗德纳斯K·纳吉K-A·勒T·J·伍斯特
Owner SOC DES PROD NESTLE SA