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Methods and systems for generating non-coding-coding gene co-expression networks

A coding gene, non-coding technology, applied in the field of generating non-coding-coding gene co-expression network and system, can solve specificity, low tissue and conditional problems

Active Publication Date: 2021-12-07
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But it is also evident that lncRNAs affect the activity of distant (trans) loci
Compounding the problem is the fact that lncRNAs are expressed at low levels and are often specific to specific tissues and conditions.

Method used

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  • Methods and systems for generating non-coding-coding gene co-expression networks
  • Methods and systems for generating non-coding-coding gene co-expression networks
  • Methods and systems for generating non-coding-coding gene co-expression networks

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Embodiment Construction

[0009] The following descriptions of specific exemplary embodiments are merely exemplary in nature and are in no way intended to limit the invention, its application or uses. In the following detailed description of embodiments of the present systems and methods, reference is made to the accompanying drawings, which form a part hereof, and in which are shown by way of illustrations in which the described systems and methods may be practiced particular embodiment. These embodiments are described in sufficient detail to enable those skilled in the art to practice the presently disclosed systems and methods, and it is to be understood that other embodiments may be utilized and structural and logical changes may be made without departing from the spirit and methods of the present system scope.

[0010] Accordingly, the following detailed description should not be viewed in a limiting sense, and the scope of the present system is defined only by the appended claims. The leading d...

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Abstract

A method for identifying coexpressed coding and noncoding genes is disclosed. The method may comprise: receiving a gene sequence; mapping the gene sequence to known coding and non-coding genes; correlating the mapped genes; and generating a co-expression network. A system for generating a co-expression network and providing the co-expression network to a user on a display is disclosed. The system may include memory, one or more processors, one or more databases, and a display.

Description

Background technique [0001] Long noncoding RNAs (lncRNAs) belong to a recently discovered class of transcripts that are suspected to have a wide range of roles in cellular functions, including gene silencing, transcriptional regulation, RNA processing, and RNA modification. However, the precise mechanisms of transcription and interactions with coding RNAs (genes) are poorly understood as they have not been annotated and difficult to measure. [0002] While the majority of the transcribed genome encodes for proteins, a substantial proportion of the genome that produces RNA transcripts does not encode for proteins. A particular class of noncoding RNAs, long noncoding RNAs (lncRNAs) (>200 nucleotides long), have been shown to affect a wide variety of cellular functions, including gene silencing, transcriptional regulation, RNA processing, and RNA grooming. However, the precise transcriptional mechanisms of lncRNAs and their interactions with coding RNAs are poorly understood...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16B25/00G16B5/00G16B20/00C12Q1/6876C12Q1/6883G16B45/00G16B20/20G16B25/10
CPCG16B5/00G16B25/00C12Q2600/178C12Q2600/158C12Q1/6883G16B20/20G16B45/00G16B25/10C12Q1/6876G16B20/00C12Q2600/112C12Q2600/118
Inventor N·班纳吉N·迪米特罗娃S·肖他尼W·F·J·费尔哈格Y·H·张
Owner KONINKLJIJKE PHILIPS NV
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