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A kind of ha nanotube bioactive coating preparation method

A biologically active and nanotube technology, applied in the field of HA nanotube bioactive coating preparation, can solve the problems of HA nanotube preparation and performance research that have not been published, and achieve the effect of promoting proliferation and differentiation and high biological activity

Active Publication Date: 2019-02-05
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, so far, there have been a large number of reports on the preparation of HA nanorods and their biological properties, but there have been no publications on the preparation and performance of HA nanotubes. Therefore, a method for preparing hydroxyapatite nanotubes is provided. It is of great significance to the performance research of hydroxyapatite nanotubes and the development of later practical applications

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  • A kind of ha nanotube bioactive coating preparation method
  • A kind of ha nanotube bioactive coating preparation method
  • A kind of ha nanotube bioactive coating preparation method

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preparation example Construction

[0025] A preparation method of HA nanotube bioactive coating, comprising the following steps:

[0026] Step 1: Using micro-arc oxidation method, in the electrolyte containing calcium and phosphorus salt, the molar ratio of calcium and phosphorus in the electrolyte is 10:1, the concentration of calcium salt is 0.2mol / L, and then test with titanium or titanium alloy The sample is the anode, the stainless steel is the cathode, and the pulse power supply is used to test the titanium or titanium alloy under the conditions of voltage 350-500V, frequency 50-500Hz, duty cycle 10-60%, and distance between cathode and anode plates 8-12cm. The sample is subjected to micro-arc oxidation treatment, the temperature of the electrolyte is maintained at 5-25°C, and the treatment time is 1-10min. After the reaction is completed, porous TiO containing Ca and P is formed on the surface of the titanium or titanium alloy sample. 2 coating;

[0027] Step 2: Then use the hydrothermal method to first...

Embodiment 1

[0032] The first step: Micro-arc oxidation, prepare an electrolyte solution with deionized water as solvent, calcium acetate and β-glycerophosphate disodium salt as solute, the molar ratio of calcium to phosphorus in the electrolyte is 10:1, and the concentration of calcium acetate 0.2mol / L, then use titanium as the anode and stainless steel as the cathode, use a pulse power supply to conduct micro-arc plasma on titanium under the conditions of voltage 400V, frequency 100Hz, duty cycle 26%, and the distance between cathode and anode plates is 8cm. Treatment, the treatment time is 3 minutes, and the temperature of the electrolyte is kept at 5-25°C, and porous TiO containing Ca and P can be formed on the titanium surface 2 coating;

[0033] The second step: hydrothermal, TiO obtained by micro-arc oxidation 2 The coating is reacted in a high-temperature and high-pressure reactor in a NaOH solution with a pH of 12. The reaction temperature is 90°C and the time is 2 hours. Therma...

Embodiment 2

[0036] The first step: micro-arc oxidation, prepare an electrolyte solution with deionized water as solvent, calcium chloride and sodium phosphate as solute, the molar ratio of calcium to phosphorus in the electrolyte is 10:1, and the concentration of calcium chloride is 0.2 mol / L, then use titanium alloy as the anode and stainless steel as the cathode, and use the pulse power supply to conduct micro-arc plasma treatment on titanium under the conditions of voltage 350V, frequency 50Hz, duty cycle 10%, and the distance between cathode and anode plates is 10cm , the treatment time is 10 minutes, and the temperature of the electrolyte is kept at 5-25°C, and porous Ca and P-containing TiO can be formed on the titanium surface 2 coating;

[0037] The second step: hydrothermal, TiO obtained by micro-arc oxidation 2 Coating in K(OH) at pH 10 2A high-temperature and high-pressure reactor reaction was carried out in the solution, the reaction temperature was 70°C, and the time was 3 ...

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Abstract

The invention discloses a preparation method for an HA nano-tube bioactive coating layer. The preparation method comprises the following steps: firstly, taking a titanium or titanium alloy sample as an anode and taking stainless steel as a cathode in an electrolyte containing calcium salt and phosphorus salt, carrying out micro-arc oxidation treatment on the titanium or titanium alloy sample through a pulse power supply, and generating a TiO2 coating layer on the surface layer of the titanium or titanium alloy sample after the reaction is concluded; secondly, carrying out primary hydrothermal reaction on the TiO2 coating layer in a strong base solution, and carrying out secondary hydrothermal reaction in a calcium-phosphorus solution after the reaction is concluded and cooling is carried out to obtain HA nano-rods; and finally, adjusting the pH value of an electrolyte taking a strong acid salt as a solute to achieve 1-4 through a strong acid in the electrolyte, taking the HA nano-rods as an anode, taking a platinum electrode as a cathode, carrying out electrochemical corrosion on the HA nano-rods through a constant-voltage power supply, that is, corroding the HA nano-rods along C-axis to obtain HA nano-tubes after the reaction is concluded. The HA bioactive coating layer synthesised through the method disclosed by the invention is of a nano-tube-shaped structure, and is high in biocompatibility and bioactivity compared with titanium and the alloy thereof.

Description

technical field [0001] The invention relates to the field of surface treatment of titanium and titanium alloy components, in particular to a method for preparing an HA nanotube bioactive coating. Background technique [0002] Due to their excellent mechanical properties, corrosion resistance and biocompatibility, titanium and titanium alloys are currently widely used in hard tissue implant materials. But it is also biologically inert. After implantation, it cannot chemically and biologically combine with the implant tissue, which limits its wider application in biological implants. So it must be surface modified. Hydroxyapatite, the main inorganic component of human bone, is often used as an implant coating material to improve cellular response and osteoconductivity due to its mineral composition similar to natural bone. Compared with other structural materials, nanotubes can promote the adhesion and reproduction of osteoblasts; implanted in animals, they can chemically co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C25D11/26C25F3/02A61L27/06A61L27/30A61L27/54
CPCA61L27/06A61L27/306A61L27/54A61L2400/18A61L2430/02C25D11/024C25D11/026C25D11/26C25F3/02
Inventor 张兰代芳憨勇
Owner XI AN JIAOTONG UNIV