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Mongolian medicine composition for clearing heat and treating mucosa diseases and extraction process thereof

A technology of composition and Mongolian medicine, applied in the field of pharmaceuticals, can solve the problems of long extraction time, large energy consumption, ethanol, hidden safety hazards, etc., and achieve the effect of enhancing the efficacy of the medicine and reducing the loss of active ingredients

Inactive Publication Date: 2017-10-10
巴图德力根
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to the consumption of a large amount of energy and ethanol in this process, ethanol is a flammable and explosive solvent, and there is a great potential safety hazard in the extraction and recovery process
While the percolation method also has the above problems, the extraction time is longer

Method used

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  • Mongolian medicine composition for clearing heat and treating mucosa diseases and extraction process thereof
  • Mongolian medicine composition for clearing heat and treating mucosa diseases and extraction process thereof
  • Mongolian medicine composition for clearing heat and treating mucosa diseases and extraction process thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0138] Preparation of reagents

[0139] Preparation of the reference solution: Accurately weigh 0.3mg of geniposide standard substance, put it into a 10mL measuring bottle, and add methanol to the scale of the measuring bottle;

[0140] Preparation of the test solution: Weigh 0.1g of the extractant of each experiment in the uniformly mixed design experiment, weigh it accurately, put it in a stoppered Erlenmeyer flask, add 25mL of methanol, weigh it, ultrasonically treat it for 20min, and let it cool , and then weighed, make up the lost weight with methanol, shake well, and filter. Precisely measure 10mL of the continued filtrate, put it in a 25mL measuring bottle, and add methanol to the mark.

[0141] systematic test

[0142] Precisely draw 10 μL of the reference solution, and inject 5 times continuously. The RSD% calculated by the peak area is 1.22, and the precision of this method is good. The results are shown in Table 7.

[0143] Table 7. Precision test of geniposide

...

Embodiment 1

[0208] The Mongolian medicinal composition for clearing away heat and eliminating stickiness has the following components in optimal parts by weight: 25 parts of Gardenia, 25 parts of Sophora flavescens, 25 parts of Chuanketong, and 15 parts of Huhuanglian. The preparation method of above-mentioned medicine comprises the following steps:

[0209] S1: Take the decoction pieces of the above four raw materials of gardenia, flavescens, akebia, and berberine, and mix them evenly;

[0210] S2: add double distilled water as decoction water, and decoct the whole components of medicinal materials together to obtain a decoction liquid;

[0211] S3: After decocting, filter the decoction obtained in S2 through a 200-mesh filter, take the filtrate, and set aside;

[0212] S4: return the filter residue obtained by filtering in S3 to S2, add decoction water, and continue decocting;

[0213] S5: combining the filtrates obtained from several decoctions in the above S3 to obtain the total fil...

Embodiment 2

[0228] On the basis of the above examples, this example further improves the specific operation steps of the extraction process. In step S1, first take the raw material of Gardenia jasmine, and enter S2 for decoction; Mix the medicines evenly, add them into the decoction of S2 gardenia, and decoct the whole ingredients together. Compared with other three herbs, gardenia has certain liver and kidney toxicity, and large dose or long-term use may cause liver and kidney damage. In order to better play gardenia liver protection, choleretic, blood pressure lowering, sedation, hemostasis, detumescence, heat clearing, purging fire, cooling blood, improving eyesight, dispelling Bada Ganxie sun, blood disease, Heyi, frequent urination and other diseases In this embodiment, gardeniae is decocted for a certain period of time, so that the active ingredients can be separated and leached early, so as to promote absorption and weaken the conversion of active ingredients to toxic ingredients. ...

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Abstract

The invention relates to a Mongolian medicine composition for clearing heat and treating mucosa diseases and an extraction process thereof. Through being considered by Mongolian medicine, the warm and heat disease is a generic term of accurate calenture due to Qisu and Xila disorder; the kinds of traditional Chinese and western medicine for treating calenture are various; the medicine has short curative effect, drug resistance and toxic and side effects. The Mongolian medicine is prepared from 10 to 30 weight parts of fructus gardeniae, 10 to 30 weight parts of radix sophorae flavescentis, 10 to 30 weight parts of caulis clematidis armandii and 5 to 20 weight parts of rhizoma picrorhizae; 1 to 30 weight parts of herba artemisiae capillaris are added; active ingredients of the Mongolian medicine are extracted by using a semi-bionic acid environment; the conformance to the Mongolian medicine matching and Mongolian medicine clinic medicine use characteristics and the characteristics of operation absorption of oral medicine in the gastrointestinal tract are realized; the active ingredient loss is low; active ingredients of iridoid glycosides, alkaloid and the like in medicinal materials can be extracted to the maximum degree; the alkaloid is not dissolved in water or is insoluble in water, and can be dissolved into a water solution of diluted acid to become salts; the salts of alkaloid are most dissolved into water; the absorption by the human body is easy, so that the medicine effect is enhanced.

Description

technical field [0001] The invention relates to a medicine, in particular to a Mongolian medicine composition with the curative effect of clearing away heat and eliminating stickiness and its extraction process. Background technique [0002] Mongolian medicine believes that febrile disease fever is a general term for acute fever caused by the abnormality of Qisu and Xila, and can be caused by sticky plague infection, abnormal weather, and improper diet. Based on the pathogenesis, febrile disease fever can be divided into eight main disease stages, each of which is a specific syndrome type, namely immature heat, increasing heat, hot disease mountain beach boundary, emptiness heat, latent heat, dryness Turbidity heat, disseminated heat, old heat, etc. Generally speaking, the initial stage of febrile disease fever is immature heat, the middle stage is increasing heat, and the final stage is febrile disease mountain beach boundary. Uncooked heat develops into simple Xiri Qisu h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/80A61P29/00A61P31/04A61P31/12A61P1/16
CPCA61K36/80A61K36/282A61K36/489A61K36/716A61K36/744A61K2236/331A61K2236/39A61K2236/51
Inventor 巴图德力根韩志强
Owner 巴图德力根
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