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Ultrafast microfluidic mixer with viscosity adaptability

An adaptable and mixer technology, applied in the direction of mixers, chemical instruments and methods, dissolution, etc., can solve the problems of small sample consumption, etc., and achieve the effect of improving mixing efficiency, increasing mixing efficiency, and shortening mixing time

Active Publication Date: 2021-04-06
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Purpose of the invention: In order to solve the problem that the existing technology cannot combine fast mixing speed and small sample consumption under high viscosity conditions, the present invention provides a mixing channel formed by splicing circular arc channels to accelerate fluid mixing and improve the adaptability to fluid viscosity. revolutionary ultrafast microfluidic mixer

Method used

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  • Ultrafast microfluidic mixer with viscosity adaptability
  • Ultrafast microfluidic mixer with viscosity adaptability
  • Ultrafast microfluidic mixer with viscosity adaptability

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Embodiment 1

[0019] Figure 2(a)-(b) shows figure 1 Partially enlarged schematic diagram of the mixing area in the middle, the mixing channel 2 of the present invention adopts an arc-shaped design; specifically, the mixing channel 2 can be an arc-shaped channel, as shown in Figure 2 (a), it can also be formed by multiple arcs The channels are connected, and the arc is preferably a semicircle; when the fluid passes through the curved mixing channel, a strong "secondary flow" will be generated in the cross section, and this "secondary flow" will be generated in the fluid in a laminar flow state Strong lateral movement, and this lateral movement will greatly increase the movement between the flow layers, thereby enhancing the mixing effect, so the mixing channel 2 adopts a circular arc design; in order to enhance the mixing effect, the mixing channel can also be composed of two The two arcs are preferably one larger and the other smaller, and the smaller arc is set on the side where the center...

Embodiment 2

[0021] The increase in the number of arcs can increase the mixing effect, but at the same time it will increase the complexity of the structure and the difficulty of processing and use; in addition, in order to make the fluid flow into the observation channel 3, the present invention further preferably adopts three arcs, Constitute the C-S type mixing channel as shown in Figure 2 (b); This C-S type mixing channel 2 is on the basis of adopting above-mentioned two circular arcs, introduces the 3rd circular arc, and concrete structure is as follows: by the first circular arc 201, The second circular arc 202 and the third circular arc 203 are connected in sequence; wherein, the first circular arc 201, namely the C-shaped channel, communicates with the end of the central channel 101, and its diameter is larger than that of the second circular arc 202 and the third circular arc The sum of the diameters of the arcs 203; the second arc 202 and the third arc 203 are spliced ​​into an S-...

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Abstract

The invention discloses an ultrafast microfluidic mixer with viscosity adaptability, which is composed of an inlet channel, a mixing channel and an observation channel in sequence; wherein, the inlet channel includes a central channel and is arranged on both sides of the central channel and connected with it. two connected side channels; the mixing channel is arc-shaped, or is formed by connecting multiple arc-shaped channels; the observation channel and the mixing channel are integrally formed or connected by splicing; the present invention has an effect on the viscosity of the fluid Strong adaptability, when the viscosity of the fluid changes greatly (1-30cp), the high mixing efficiency of more than 90% can still be obtained, and the mixing time is as short as a few microseconds; the manufacturing process of the mixer is simple, only A standard planar photolithography process is required to complete the production of the entire mixer mold, without complex processes such as multiple exposures and alignments.

Description

technical field [0001] The invention relates to a microfluidic chip, in particular to an ultrafast microfluidic mixer with viscosity adaptability. Background technique [0002] In recent years, Lab-on-a-chip (Lab-on-a-chip) has been widely researched and applied in the fields of biology, chemistry, medicine, etc. Microfluidic mixer is an important part of it. In the study of fast reaction kinetics , an ultrafast microfluidic mixer must be used. [0003] At present, most ultrafast microfluidic mixers work by increasing the Reynolds number of the mixing channel with a large flow rate to increase the mixing effect, but when the fluid is at a low Reynolds number, the mixing efficiency will be greatly reduced. However, the real environment of biological reactions is a cell environment with high viscosity. The increase of viscosity is accompanied by the decrease of the Reynolds number in the microfluidic mixer, which will lead to a significant decrease in the mixing efficiency of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01F13/00
CPCB01F33/30
Inventor 朱利陈科祥陆辉崔一平
Owner SOUTHEAST UNIV