Time-of-flight mass spectrometer with dual-field acceleration region

Abstract

The invention relates to the technical field of mass spectrometry, in particular to a time-of-flight mass spectrometer with a dual-field acceleration region. The time-of-flight mass spectrometer comprises a first electric field acceleration region, a second electric field acceleration region and a free flight region which are sequentially arranged in a vacuum cavity, an ion source is arranged at a front end of the first electric field acceleration region, an ion detector is arranged at a rear end of the free flight region, and the distance between electrodes at two sides of the second electric field acceleration region is adjustable. By a dual-field acceleration field design method of a dual-field acceleration spectrometer, the distance between pole plates and a voltage division ratio can be adjustable, and the resolution and the sensitivity cannot be damaged. Moreover, compared with an ion trap-time-of-flight spectrometry design in a commercial instrument, the design provided by the invention has the advantages that the distance of a segment of an acceleration field is saved, and the miniaturization and the portability of the instrument are facilitated.

Description

Technical field [0001] The invention relates to the technical field of mass spectrometry, in particular to a time-of-flight mass spectrometer with a dual-field acceleration zone. Background technique [0002] As an outstanding representative of analytical and testing scientific instruments, mass spectrometers have the advantages of the highest sensitivity and the strongest applicability. They play an irreplaceable important role in scientific research and production practice, and their applications cover various fields of national economy, people’s livelihood and safety information. [0003] In mass spectrometry, the molecules of the substance to be measured are ionized and then differentiated and quantitatively analyzed according to different mass-to-charge ratios (the ratio of mass to charge) under the control of an electromagnetic field according to spatial position and time. Time-of-flight mass spectrometry is a very widely used mass spectrometry technology. There are two main...

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Problems solved by technology

[0018] In actual work, the geometric parameters and voltage parameters of the dual-field acceleration region of time-of-flight mass spectrometry often need to solve the theoretical values ​​according to the Taylor formula, or use simulation software to simulate the corresponding parameters, and then design and process the corresponding parameters according to the theoretical values ​​or simulated values. However, in the actual debugging process, due to the influence of factors such as processing errors and assembly errors, the actual effect will have a large deviation from the theoretical value. At the same time, the parameters of processing and assembly cannot be adjusted immediately. If there is no change, it will bring a lot of inconvenience to the experiment and prototype debugging

[0019] In addition, in order to pursue a higher resolution, ions often need to pass through a smaller slit before the double-field acceleration region, so as to reduce the impact of the initial spatial dispersion on the resolution, but at the same time, the number of ions will vary. Large loss, not conducive to the sensitivity of the instrument

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