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Application of dextromethorphan hydrobromide in the treatment of acute and chronic renal fibrosis

A technology for dextromethorphan hydrobromide and renal fibrosis, applied to medical preparations containing active ingredients, organic active ingredients, pharmaceutical formulas, etc., to prevent and inhibit the weakening of renal function

Active Publication Date: 2020-07-21
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the research on the mechanism of RIF development is the key to find targets for delaying or reversing the progression of CKD, but currently there is no effective treatment for clinical application

Method used

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  • Application of dextromethorphan hydrobromide in the treatment of acute and chronic renal fibrosis
  • Application of dextromethorphan hydrobromide in the treatment of acute and chronic renal fibrosis
  • Application of dextromethorphan hydrobromide in the treatment of acute and chronic renal fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1, configure dextromethorphan hydrobromide injection.

[0026] Dextromethorphan hydrobromide (molecular formula C 18 h 25 NO·HBr·H 2 O, referred to as DXM), white powder, purchased from Sigma-Aldrich Company. Take 100mg of DXM powder, dissolve it with normal saline to 10ml, and prepare a 10mg / ml mother solution. Before use, take 0.5ml, 1.5ml, and 3ml of the mother solution, dilute it with normal saline to 10ml, and prepare 0.5mg / ml, 1.5mg / ml, and 3mg / ml injections for low, medium, and Drug use in the high-dose group.

Embodiment 2

[0027] Example 2, test preparation.

[0028] 8-week-old healthy male C57BL / 6 mice were purchased from the Experimental Animal Center of Zhejiang University, and the right renal artery was clamped and opened for 45 minutes to cause ischemia-reperfusion injury of the right kidney and lead to chronic renal fibrosis. Two weeks after ischemia / reperfusion, mice were randomly divided into 4 groups, sham operation group (Control), ischemia-reperfusion (IR) group, IR+low dose (5 mg / kg, LD) group, IR+medium dose (15 mg / kg, MD) group, IR+high dose (30 mg / kg, HD) group, 8 rats in each group. The sham operation group was given normal drinking water.

Embodiment 3

[0029] Example 3, verifying the effect of DXM on reducing serum creatinine in ischemic mice.

[0030] On the basis of Example 2, after ischemia, the mouse serum creatinine was measured every two weeks, and the results were significantly different using GraphPad Prism 7.0 for Two-way ANOVA analysis, the results are as follows figure 1 It was shown that the serum creatinine of renal ischemia mice before medication was significantly higher than that of the sham operation group; after 2 weeks (4wk) of medication, the serum creatinine of mice in the high-dose group decreased first, which was significantly lower than that of the non-medication group; after 4 weeks of medication (6wk) After 6 weeks (8wk) and 6 weeks (8wk), the high, medium and low doses all have a significant down-regulation effect on the serum creatinine value of mice, and there is a certain dose effect. .

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Abstract

The invention provides application of dextromethorphan hydrobromide to treatment of acute and chronic renal fibrosis. The molecular formula of dextromethorphan hydrobromide is C18H25NO HBr H2O. The dextromethorphan hydrobromide has the shape of white powder and the dosage form of injection; the injection is obtained after diluting mother liquid prepared from dextromethorphan hydrobromide powder and physiological saline. The invention provides the application of the existing medicine (dextromethorphan hydrobromide) to the treatment of the acute and chronic renal fibrosis. The technical scheme and the technical effect can prove that the dextromethorphan hydrobromide can be used for effectively preventing and inhibiting the long-period prognostic renal function weakening and renal fibrosis due to renal ischaemia; the ingredients can be used for medium-long-period renal function protection after the acute kidney injury; the novel scheme is provided for the acute chronic renal fibrosis; the novel direction is provided for the medicine study of the dextromethorphan hydrobromide.

Description

technical field [0001] The present invention relates to a new application of dextromethorphan hydrobromide (DXM), especially the treatment plan and application for treating acute and chronic renal fibrosis. Background technique [0002] The incidence of chronic kidney disease (CKD) in my country is about 10.8%. With the further aggravation of population aging and other problems, its threat to public health and the burden it brings to society have become increasingly prominent. CKD patients have a significantly higher risk of cardiovascular and cerebrovascular diseases, infections, etc., and can lose labor force or even die due to complications before developing end-stage renal disease (ESRD). Renal interstitial fibrosis is a characteristic pathological change of CKD, manifested as pathological fibrous matrix deposition in renal tubules and peritubes, is a common path of CKD progression and a sign of poor prognosis, and its severity is a determinant of renal function deterior...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/485A61K9/08A61P13/12
CPCA61K9/0019A61K9/08A61K31/485A61K47/02
Inventor 沈佳陈江华王仁定周静怡
Owner ZHEJIANG UNIV
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