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Traditional Chinese medicine compound injection for treating haemophilus parasuis disease and preparation method thereof

A technology for Haemophilus suis disease and compound injection, which is applied in the directions of antibacterial drugs, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems of high hazard and mortality, and can not play a good prevention and control effect.

Inactive Publication Date: 2017-10-20
SHENYANG VICA ANIMAL HUSBANDRY TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In summary, based on the high hazards and high mortality of the disease in the pig industry, and the use of antibiotics and vaccines cannot achieve a good control effect, there is an urgent need to research and develop a safe method that can effectively prevent and treat the disease. High, no drug resistance, no residual drugs

Method used

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  • Traditional Chinese medicine compound injection for treating haemophilus parasuis disease and preparation method thereof
  • Traditional Chinese medicine compound injection for treating haemophilus parasuis disease and preparation method thereof
  • Traditional Chinese medicine compound injection for treating haemophilus parasuis disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 Chinese medicine compound injection formula

[0025] Formula 1: Honeysuckle 8kg, Dandelion 8kg, Scutellaria baicalensis 7kg, Atractylodes macrocephala 4kg, licorice 3kg, total 30kg;

[0026] Formula 2: Honeysuckle 8kg, Dandelion 8kg, Scutellaria baicalensis 6kg, Atractylodes macrocephala 4kg, licorice 4kg, total 30kg;

[0027] Formula 3: Honeysuckle 8kg, Dandelion 7kg, Scutellaria baicalensis 7kg, Atractylodes macrocephala 4kg, Licorice 4kg, total 30kg;

[0028] Formula 4: Honeysuckle 9kg, Dandelion 8kg, Scutellaria baicalensis 7kg, Atractylodes macrocephala 3kg, licorice 3kg, 30kg in total.

Embodiment 2

[0029] Example 2 Preparation method

[0030] (1) Weigh honeysuckle, add 8-10 times the amount of 15% ethanol to reflux and extract twice, each time for 1 hour, combine the extracts, concentrate under reduced pressure to a clear paste with a relative density of 1.15-1.20, add ethanol to make the paste containing Alcohol content reaches 65%, stand still for 24h, filter, add ethanol to the filter residue to make the alcohol content reach 65%, stand still for 24 hours, filter, combine the filtrate twice, concentrate under reduced pressure, the obtained concentrated solution volume is the total filtrate 1 / 10, refrigerated for later use;

[0031] (2) Weigh dandelion, scutellaria baicalensis, Atractylodes macrocephala, and licorice, combine them with the dregs of honeysuckle, add 4-10 times the total weight of water, decoct twice for 1.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to relative For clear ointment with a density of 1.12-1.15, add ethan...

Embodiment 3

[0035] Embodiment 3 application effect test

[0036] In order to verify the safety of clinical use of Chinese medicine compound injection of the present invention and the therapeutic effect to Haemophilus parasuis disease, further illustrate by following test:

[0037] 1 Acute toxicity test

[0038] 1.1 Pre-test

[0039] Take 20 mice, conduct a pre-test according to the sequential method, observe continuously for 7 days, and measure the intraperitoneal injection of mice

[0040] The 100% lethal dose is 34ml / kg, which is 102000mg / kg.

[0041] 1.2 LD50 Determination of

[0042] Take 50 healthy mice with a body weight of 20±2g, divide them into random groups, 10 mice / group, half male and half male, artificial lighting for 12 hours, feeding and observation for 7 days, fasting without food and water within 12 hours before administration and within 4 hours after administration; One-time intraperitoneal injection of an appropriate dose, the injection volume is 0.2ml / 10g body weig...

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Abstract

The invention discloses a traditional Chinese medicine compound injection for treating haemophilus parasuis disease. The traditional Chinese medicine compound injection is prepared by extracting honeysuckle, dandelion, scutellaria baicalensis, bighead atractylodes rhizome and glycyrrhiza by means of water extraction and alcohol precipitation. Compared with the prior art, the traditional Chinese medicinal materials have a good coordinated synergistic effect, are highly sensitive to haemophilus parasuis, can enhance the immunity of human body and coordinate physiological metabolism comprehensively, and jointly play roles of clearing away heat and toxic materials, soothing the liver and relieving heat, moistening lung to arrest cough, drying damp and eliminating phlegm, tonifying spleen and qi and resisting and inhibiting bacteria. The traditional Chinese medicine compound injection disclosed by the invention has the advantages of being simple in preparation process, convenient to use, free of drug residues and toxic and side effects and good in effect. The cure rate on haemophilus parasuis can reach 85% or above.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to a traditional Chinese medicine compound injection for treating Haemophilus parasuis disease and a preparation method thereof. Background technique [0002] Haemophilus parasuis, also known as porcine polyserositis and arthritis or Glasser's disease , sdisease) is a conditional infectious disease of pigs caused by Haemophilus parasuis (HPS). This bacterium is a common bacterium in the upper respiratory tract of pigs, and healthy pigs with bacteria can become a source of infection. When the protection of maternal antibodies is lost after transfer and weaning, and other diseases lead to decreased immunity, symptoms may appear, pathogenic bacteria are discharged, and the transmission is mainly through the respiratory tract. The disease only occurs in pigs, and can be infected from 2-week-old piglets to 4-month-old fattening pigs, but it is more common in nursery pigs of 5-8 weeks o...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K9/08A61P31/04
CPCA61K9/0019A61K9/08A61K36/284A61K36/288A61K36/355A61K36/484A61K36/539A61K47/26A61K2300/00
Inventor 田凯王洪礼赵宝凯
Owner SHENYANG VICA ANIMAL HUSBANDRY TECH
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