Preparation method of styptic powder containing calcium chloride and sodium alginate

Abstract

The invention discloses a preparation method of styptic powder containing calcium chloride and sodium alginate. The sodium alginate is dissolved in water, or the sodium alginate and other raw materials are dissolved in water, then freeze drying is performed, a freeze drying sample is smashed into fine powder A, then the calcium chloride is smashed into fine powder B, the fine powder B is added into the fine powder A, and even mixing is performed. The prepared styptic powder does not contain a toxic chemical agent, has the effects of inhibiting bacteria, promoting wound healing and inhibiting scar formation, can uniformly and rapidly absorb moisture in blood on the wound surface after scattered and coated, does not form a 'white core' and is convenient to use, efficient, free of side effects and excellent in styptic effect.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a preparation method of hemostatic powder containing calcium chloride and sodium alginate. Background technique [0002] With the continuous advancement of medical technology, new medical materials and related technologies have been well developed. Among them, the development and improvement of hemostatic materials are conducive to improving the problems of surgical bleeding and bleeding, which is of great significance and has become a hot research topic in the field of medicine. [0003] War wounds, trauma, emergency animal husbandry and surgical operations will all cause bleeding. This problem needs to be solved urgently. The normal human body has the function of hemostasis. Slow and small amount of bleeding can stop bleeding by relying on its own function. The body cannot stop the bleeding by itself, nor can it only rely on ordinary hemostatic bandages to stop the bleeding. If the pat...

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Problems solved by technology

[0004] At present, the clinically used hemostatic materials mainly include fibrin glue, collagen, gelatin sponge and cellulose hemostatic materials. These materials have achieved good results in animal experiments and clinical applications, but there are also some shortcomings: The raw material is derived from animal tissue, which is a foreign protein, which is prone to rejection and has potential sensitization; gelatin absorbs slowly, generally more than 4 weeks, which will increase the risk of wound infection; cellulose, the human body lacks enzymes to degrade it , the degradation time is long, which may bring side effects such as infection to the patient

[0009] 1. Modified starch-based hemostatic powder requires the use of a variety of toxic chemical reagents, which has potential residual toxicity problems;

[0010] 2. Collagen-based hemostatic powder is derived from animals, is a foreign protein, is prone to repellency, has potential sensitization, and absorbs slowly, generally taking more than 4 weeks;

[0011] 3. Most hemostatic powders only have hemostatic effect, no antibacterial effect, promote wound healing, and inhibit scar formation

[0012] 4. In the existing preparation method of hemostatic powder containing calcium chloride and sodium alginate, sodium alginate and calcium chloride are usually used to form calcium alginate first, then freeze-dried and crushed for use. The powder prepared by this method has toughness Large, difficult to crush, and has no water absorption capacity, no in-situ gel will be formed when it encounters blood in the wound

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