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A method for supercritical carbon dioxide extraction of ursolic acid from Ligustrum lucidum

A technology of carbon dioxide and Ligustrum lucidum, applied in organic chemistry, steroids, bulk chemical production, etc., can solve the problems of long extraction time, large amount of organic solvent, environmental pollution, etc., and achieve good reproducibility and high extraction efficiency High, process-stable effect

Active Publication Date: 2020-05-12
瑞康东方医学研究(北京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In order to solve the problems in the prior art that the extraction time of ursolic acid of Ligustrum lucidum is long, the amount of organic solvent is large, and the organic solvent is difficult to recycle, causing environmental pollution and solvent residues, the invention provides a supercritical carbon dioxide extraction of Ligustrum lucidum bearberry sour method

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  • A method for supercritical carbon dioxide extraction of ursolic acid from Ligustrum lucidum
  • A method for supercritical carbon dioxide extraction of ursolic acid from Ligustrum lucidum

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Embodiment 1

[0023] The method of embodiment 1 supercritical carbon dioxide extraction Ligustrum lucidum ursolic acid

[0024] S1, pretreatment: pulverize Ligustrum lucidum to 50 mesh for later use;

[0025] S2, feeding: take by weighing 200g of privet fruit powder pulverized in step S1, put it into the extraction kettle of the supercritical carbon dioxide extraction device, tighten the extraction kettle cover, and check whether the separation kettle cover and the relevant valve are in a closed state;

[0026] S3. Heating process: start the power supply, connect the cooling water, start the refrigerant switch, and turn on the heating switch of the extraction kettle and the separation kettle, and set the temperatures of the extraction kettle and the separation kettle I, II, and III to 35°C and 35°C respectively. ℃, 45℃, 45℃;

[0027] S4. Boosting process: When the temperature of the refrigerator drops to 5°C, and the temperature of the extraction kettle and the separation kettle reaches th...

Embodiment 2

[0029] The method of embodiment 2 supercritical carbon dioxide extraction Ligustrum lucidum ursolic acid

[0030] S1, pretreatment: pulverize Ligustrum lucidum to 50 mesh for later use;

[0031] S2, feeding: take by weighing 200g of privet fruit powder pulverized in step S1, put it into the extraction kettle of the supercritical carbon dioxide extraction device, tighten the extraction kettle cover, and check whether the separation kettle cover and the relevant valve are in a closed state;

[0032] S3. Heating process: start the power supply, connect the cooling water, start the refrigerant switch, and turn on the heating switch of the extraction kettle and the separation kettle, and set the temperatures of the extraction kettle and the separation kettle I, II, and III to 40°C and 55°C respectively. ℃, 45℃, 45℃;

[0033] S4. Boosting process: When the temperature of the refrigerator drops to 5.5°C, and the temperature of the extraction kettle and the separation kettle reaches ...

Embodiment 3

[0035] The method of embodiment 3 supercritical carbon dioxide extraction Ligustrum lucidum ursolic acid

[0036] S1, pretreatment: pulverize Ligustrum lucidum to 50 mesh for later use;

[0037] S2, feeding: take by weighing 200g of privet fruit powder pulverized in step S1, put it into the extraction kettle of the supercritical carbon dioxide extraction device, tighten the extraction kettle cover, and check whether the separation kettle cover and the relevant valve are in a closed state;

[0038] S3. Heating process: start the power supply, connect the cooling water, start the refrigerant switch, and turn on the heating switch of the extraction kettle and the separation kettle, and set the temperatures of the extraction kettle and the separation kettle I, II, and III to 55°C and 45°C respectively. ℃, 45℃, 45℃;

[0039]S4. Boosting process: When the temperature of the refrigerator drops to 6°C, and the temperature of the extraction kettle and the separation kettle reaches the...

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Abstract

The invention relates to a method for extracting ursolic acid from a glossy privet fruit through supercritical carbon dioxide. The method comprises the processes of pre-treatment, feeding, heating, boosting, analysis and computation and the like. The glossy privet fruit is crushed and placed in an extraction kettle of a supercritical carbon dioxide extraction device, the temperatures and the pressures of the extraction kettle and separation kettles are set respectively, extractants are collected from the separation kettles after the extraction time is up, the weights of the extractants are weighed, quantitative analysis is performed on ursolic acid through the high performance liquid chromatography and the percentage composition of ursolic acid is calculated. The method has the technical advantages that supercritical carbon dioxide is adopted to extract ursolic acid from the glossy privet fruit, follow-up treatment is avoided, the extraction efficiency is high, the color state is good, and the process is stable and good in repeatability.

Description

technical field [0001] The invention belongs to the technical field of plant seed extraction, and in particular relates to a method for extracting ursolic acid from Ligustrum lucidum by supercritical carbon dioxide. Background technique [0002] Ligustrum lucidum is the dry and mature fruit of privet privet, a plant of the Oleaceae family. It was first recorded in the "Shen Nong's Herbal Classic" in the Eastern Han Dynasty. White, dim eyesight, internal heat and thirst, bone steaming and hot flashes. It mainly contains terpenoids, flavonoids, phenylethanol glycosides, volatile oils, phospholipids, polysaccharides, fatty acids, amino acids and other chemical components. , anti-tumor and other pharmacological effects. Ursolic acid is the main active ingredient in Ligustrum lucidum, which has various biological effects such as sedative, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, and lowering blood sugar. Ursolic acid also has obvious antioxidant function and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00
CPCC07J63/008Y02P20/54
Inventor 郭姣肖雪
Owner 瑞康东方医学研究(北京)有限公司
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