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A kind of medicine for treating Parkinson's and its preparation method, detection method and application
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A detection method and technology of traditional Chinese medicine, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of technical difficulty, inefficiency, and inability to popularize
Inactive Publication Date: 2018-06-29
朱建友
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[0004] At present, there is no Chinese medicine composition for the treatment of Parkinson's disease and Parkinson's syndrome in the market. The treatment of Parkinson's disease and Parkinson's syndrome mainly includes drug therapy and surgical treatment. The surgical therapy has strict indications ( Some patients with primary Parkinson's disease), about 70% recurrence rate, high technical difficulty, surgical complications, high price and other factors, therefore, it is only limited to a small number of patients in large hospitals and cannot be popularized, while a large number of patients still Mainly rely on drug therapy
The current drug treatment is mainly based on western medicine. The commonly used drugs are divided into dopamine preparations, such as levodopa, madopar, and sinine, which are the main drugs for the treatment of Parkinson's disease. In addition, there are dopaminereceptor stimulators Drugs, such as bromocriptine, Xieliangxing, etc., anticholinergic drugs, such as Antan, etc. In addition, there are drugs that increase the release of dopamine, such as amantadine, drugs that inhibit the degradation of dopamine, and most of the drugs used to treat Parkinson's disease There are many side effects. Most patients with long-term application have hallucinations, dyskinesia, hypotension, stomach discomfort, severe heart failure, arrhythmia, psychosis, movement disorders and other adverse reactions. Special problems such as "end-of-dose phenomenon", "dose peak hyperactivity disorder", and many comorbidities such as coronary heart disease, hypotension, diabetes, glaucoma, stomach disease, etc., limit the application of western medicine due to adverse reactions
And dopamine replacement therapy is often less effective or even ineffective for Parkinson's syndrome
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[0242] S1: Take galangal, crush it to 400 mesh, reflux extract with 12 times the amount of 10% glacial acetic acid solution twice, each time for 3 hours, filter the extract, adjust the filtrate to pH 7 with NaOH solution, concentrate to obtain galanga ginger extract;
[0243] S2: Take Cyperia cyperi, crush it to 400 meshes, use 12 times the amount of 60% ethanol solution to ultrasonically extract twice, each time for 40 minutes, filter the extract, recover the ethanol until it has no alcohol smell, and obtain the extract of Cyperia cyperi;
[0244] S3: put the galangal extract and the cypera cyperus extract into the reaction kettle in turn, stir at 75° C. for 3 hours to obtain a reacted mixed solution, concentrate and dry the reacted mixed solution to obtain the product.
[0263] S1: Take galangal, crush it to 400 mesh, reflux extract with 12 times the amount of 10% glacial acetic acid solution twice, each time for 3 hours, filter the extract, adjust the filtrate to pH 7 with NaOH solution, concentrate to obtain galanga ginger extract;
[0264] S2: Take Cyperia cyperi, crush it to 400 meshes, use 12 times the amount of 60% ethanol solution to ultrasonically extract twice, each time for 40 minutes, filter the extract, recover the ethanol until it has no alcohol smell, and obtain the extract of Cyperia cyperi;
[0265] S3: Put galangal extract and Cyperuscyperus extract into the reaction kettle in turn, stir at 75°C for 3 hours to obtain a mixed solution after reaction, concentrate and dry the mixed solution after reaction, and obtain mixed extraction of traditional Chinese medicine thing;
[0266] S4: Take the mixed extract of traditional Chinese medicine, add ap...
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Abstract
The invention discloses a traditional Chinese medicine composition for treating Parkinson's disease, and relates to a drug for treating Parkinson's disease and a preparation method, a detection method and applications thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 500 parts of galangal rhizome and 500 parts of vinegar processed rhizoma cyperi. The invention also provides a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine theory and the modern pharmacological research are combined. The advantages of galangal rhizome and vinegar processed rhizoma cyperi are integrated. The curative effects on Parkinson's disease of galangal rhizome and vinegar processed rhizoma cyperi are exerted maximally by combining two components. The Parkinson's disease and symptoms of Parkinson's disease are relieved, and the life quality of Parkinson's disease patients is improved.
Description
technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating Parkinson's and a preparation method thereof. Background technique [0002] Parkinson's disease and Parkinson's syndrome (Parkinson, PD) are clinical common diseases, especially along with population aging, the proportion and absolute number of elderly population increase gradually, as the Parkinson's disease and Parkinson's syndrome of senile degenerative encephalopathy Its incidence and prevalence are rapidly increasing. Parkinson's disease (PD) is a degenerative disease of the central nervous system with progressive motor dysfunction as the main clinical manifestation. Tremor, stiffness and decreased movement are the most important clinical manifestations. [0003] In the existing patent application number CN201210402024.0 "Application of arctiin and aglycon in anti-Parkinson's disease", arctiin and...
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