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Polypeptide-k compound plant medicine for treating diabetes and preparation method of polypeptide-k compound plant medicine

A technology of balsam pear polypeptide and botanical medicine, applied in the field of diabetes medicine, can solve the problems of lack of quality controllability and content of key components, inability to guarantee product efficacy stability and significance, long preparation time period, etc., to ensure stability and significant, significant hypoglycemic effect, and the effect of eliminating diabetic complications

Inactive Publication Date: 2017-12-01
李玉保 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although people have realized that bitter melon is a kind of herbal medicine raw material with hypoglycemic effect, and apply it in diabetes treatment medicine, there are some problems at the same time: one is that the above-mentioned literature and relevant plant medicines for treatment of diabetes mostly use various Such formula raw materials are directly pulverized and sieved before taking, or directly decocted with water or pulverized and then decocted with water. There is no quality controllability and content of key ingredients, and the s

Method used

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  • Polypeptide-k compound plant medicine for treating diabetes and preparation method of polypeptide-k compound plant medicine
  • Polypeptide-k compound plant medicine for treating diabetes and preparation method of polypeptide-k compound plant medicine
  • Polypeptide-k compound plant medicine for treating diabetes and preparation method of polypeptide-k compound plant medicine

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[0050] The present invention also provides a preparation method of bitter melon polypeptide compound botanical medicine for treating diabetes, which comprises the following steps: 3 to 5 parts of bitter melon polypeptide extract, 2 to 4 parts of American ginseng extract, 1 to 3 parts of kudzu root extract, 1~3 parts of Astragalus extract, 0.0006~0.0008 parts of chromium additives and 3~12 parts of fillers, dispersants and disintegrants and other carrier auxiliary materials are mixed uniformly, dried and sieved, and mixed with vibration mill type ultrafine pulverization to obtain a particle size of less than 10μm Medicinal powder; using wet granulation method, the mixed medicinal powder and the ethanol solution of the binder hydroxypropyl cellulose HPC are mixed to make soft materials, and after granulation, dry at 35-55°C for 3 to 5 hours and pass through a 40-mesh screen for granulation After the content is determined, lubricant is added into tablets according to the specificat...

Example Embodiment

[0069] Example 1

[0070] Example 1 provides a bitter gourd polypeptide compound botanical medicine for treating diabetes. The specific preparation steps are as follows:

[0071] Preparation of Bitter Gourd Polypeptide Extract: Choose fresh bitter gourd with longer growth period, greenish yellowish and full bitter gourd as raw material. The raw bitter gourd is washed with tap water and then washed with electrolytic high-concentration ozone water. The ozone concentration in the washing water is 15mg / L, the water flow is 300L / h to reduce pesticide residues and microbial residues. The cleaned bitter gourd raw material is beaten and crushed into liquid material that passes through a 20-mesh screen.

[0072] Pour the bitter melon raw material after beating and crushing into an ultrasonic-assisted extraction tank, and add 8 mass times of purified water at 50°C, adjust the pH of the system by buffer salt ≈ 7, and perform ultrasonic-assisted countercurrent extraction 3 times, each for 30 m...

Example Embodiment

[0074] Example 2

[0075] Example 2 provides a bitter gourd polypeptide compound botanical medicine for treating diabetes. The specific preparation steps are as follows:

[0076] Preparation of Bitter Gourd Polypeptide Extract: Choose fresh bitter gourd with a long growth period, greenish yellowish and full bitter gourd as the raw material, and clean the raw bitter gourd with tap water and then electrolytic high-concentration ozone water. The ozone concentration in the water is 20mg / L , The water flow is 450L / h to reduce pesticide residues and microbial residues. The cleaned bitter gourd raw material is beaten and crushed into liquid material that passes through a 20-mesh screen. Pour the bitter melon raw material after beating and crushing into an ultrasonic-assisted extraction tank, and add 5 mass times of purified water at 38°C, adjust the pH of the system by buffer salt to 6.7, and perform ultrasonic-assisted countercurrent extraction twice, each for 60 minutes. Centrifuge wi...

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Abstract

The invention provides polypeptide-k compound plant medicine for treating diabetes and a preparation method of the polypeptide-k compound plant medicine and belongs to the technical field of diabetes drugs. The plant medicine comprises, by weight, 3-5 parts of a polypeptide-k extract, 2-4 parts of an American ginseng extract, 1-3 parts of a kudzu root extract, 1-3 parts of an astragalus extract, 0.0006-0.0008 part of chromium and 3-12 parts of auxiliaries. The content of polypeptide-k protein in the polypeptide extract is more than 25%, the content of total saponins in the American ginseng extract is more than 15%, the content of total flavonoids in the kudzu root extract is more than 40%, and the content of astragalus polysaccharides in the astragalus extract is more than 15%. A great deal of natural active polypeptide-k with specific molecular weight and sequences capable of stably controlling the blood glucose metabolism function can be extracted, separated and purified, and other complications of diabetes can be remarkably alleviated or removed by combining with the unique formula of traditional Chinese medicine. The invention further provides a preparation method of the above plant medicine.

Description

technical field [0001] The invention relates to the technical field of diabetes medicines, in particular to a bitter gourd polypeptide compound herbal medicine for treating diabetes and a preparation method thereof. Background technique [0002] With the continuous improvement of people's living standards and the rapid development of social economy, the number of diabetic patients in my country has shown a rapid growth trend, accounting for about one-third of the total number of diabetic patients in the world. At present, the incidence of diabetes in my country is as high as 9.6%, and the number of diabetic patients has exceeded 110 million, and the number of patients is still increasing year by year. The harm of diabetes is huge, and the complications of diabetes accompanied by diabetes also pose a huge threat to the health and life of patients. Diabetes is called diabetes in ancient times, and it refers to a syndrome characterized by polydipsia, polyuria, polyphagia, weig...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K36/42A61K9/20A61P3/10A61K33/24A61K36/488
CPCA61K9/2054A61K33/24A61K36/258A61K36/42A61K36/481A61K36/488A61K38/011A61K2300/00
Inventor 何静仁李玉保
Owner 李玉保
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