Photothermal therapy probe based on photothermal nanomaterial

A nanomaterial and photothermal therapy technology, applied in the field of medical devices, can solve the problems of inability to achieve therapeutic effects, low photothermal conversion efficiency, etc., and achieve the effects of simple structure, small wound surface, and convenient operation.

Active Publication Date: 2017-12-01
EAST CHINA NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, patents on photothermal therapy probes include ZL96101822.4; ZL02286746.5. The patents of these photothermal probes only introduce laser light into diseased tissue parts through transparent probes. These probes do not involve the application of photothermal nanomaterials. Their mechanism The treatment is carried out through the light energy absorbed by the lesion tissue and then converted into heat energy. The light-to-heat conversion efficiency of this mechanism is very low, and it cannot achieve a good therapeutic effect.

Method used

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  • Photothermal therapy probe based on photothermal nanomaterial
  • Photothermal therapy probe based on photothermal nanomaterial
  • Photothermal therapy probe based on photothermal nanomaterial

Examples

Experimental program
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Embodiment 1

[0031] Experiment on heating egg white solution

[0032] The photothermal nanomaterial 2 of the present invention is selected to fill the space of the photothermal material filling area 12, and the end of the optical fiber 3 is a direct type 31 ( figure 2 ); the region of the probe head 11 and 12 of the present invention is inserted into 1 ml of egg white solution, the wavelength of the laser source is 808 nanometers of continuous laser, the laser output power is 1 watt, and the irradiation time is 10 minutes. Figure 4 It can be seen that this embodiment proves that the present invention can effectively increase the temperature of the egg white solution around the probe and impel the denaturation of the egg white protein (such as Figure 4 ).

Embodiment 2

[0034] Tumor Killing Experiments in Mouse Tumor Models

[0035] In order to further confirm that the present invention can be used for clinical treatment. A subcutaneous mouse tumor model was established. The photothermal nanomaterial 2 of the present invention is selected to fill the space of the photothermal material filling area 12, and the end of the optical fiber 3 is a direct type 31 ( figure 2 ); insert the probe heads 11 and 12 of the present invention percutaneously into the tumor, and then perform photothermal treatment (the laser output power is 1 watt, and the irradiation time is 5 minutes). Figure 5 It has been shown that the photothermal therapy probe can effectively heat the lesion site of the tumor tissue to a temperature above 50 degrees Celsius to achieve the purpose of ablation of the tumor.

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Abstract

The invention discloses a photothermal therapy probe based on a photothermal nanomaterial. The photothermal therapy probe comprises a cylindrical shell with a closed end, the photothermal nanomaterial arranged in the closed end in the shell, an optical fiber for illuminating the photothermal nanomaterial, and a temperature sensor close to the inner wall of the closed end of the shell. The shell is a hard material and provides the ability of the protection of internal devices and tissue puncture. An optical fiber guides laser into the internal part of a probe. The photothermal nanomaterial converts light energy into high-temperature heat energy, and the temperature sensor monitors and controls the terminal temperature of the probe. According to the photothermal therapy probe, the shell is filled with the photothermal nanomaterial, the light energy is converted into the heat energy, the probe reaches a tissue lesion part through minimal invasion, then through an efficient photothermal conversion mechanism of the photothermal nanomaterial, the killing of tumor and other disease tissue cells is implemented, and the photothermal therapy probe has the advantages of a simple structure, convenient operation, a small wound surface, efficient treatment and high accuracy.

Description

technical field [0001] The invention relates to the technical field of medical devices, a device for minimally invasive photothermal therapy, especially a photothermal therapy probe based on photothermal nanomaterials, which can be used to treat tumors and other lesions in different tissues and organs of the human body organize. Background technique [0002] Nanomaterial-mediated photothermal therapy is a new treatment method that converts light energy into heat energy through special nanomaterials to kill tumors and other diseased tissue cells through local high temperature. During the treatment, the nanomaterials need to be administered into the human body through intravenous infusion, and then the photothermal nanomaterials are enriched to the lesion site through the blood circulation, and then the lesion site is irradiated with laser light to implement time- and space-controllable photothermal therapy. At present, relevant photothermal nanomaterial preparations have ent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/06A61N5/067A61K41/00
CPCA61K41/0052A61N5/0625A61N2005/0626A61N2005/0664A61N5/067
Inventor 张强
Owner EAST CHINA NORMAL UNIV
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