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Synthesis process of azoxystrobin intermediate compound benzofuranone

A technology of benzofuranone and synthesis process, applied in directions such as organic chemistry, can solve problems such as long route, achieve the effects of simple operation, lower cost and overcoming long production process route

Inactive Publication Date: 2017-12-01
ANHUI GUANGXIN AGROCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method is cheap and easy to obtain raw materials, the operation is simple, but the route is long

Method used

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  • Synthesis process of azoxystrobin intermediate compound benzofuranone

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Embodiment 1

[0032] First put the raw material o-chlorophenylacetic acid into the synthesis kettle, then add catalyst and liquid caustic soda to the aforementioned synthesis kettle, heat up to 100°C for reaction; secondly, after the reaction of the aforementioned synthesis kettle is finished, cool down the temperature of the synthesis kettle to room temperature; then Filter the material in the synthesis kettle that was cooled to room temperature, and recover the catalyst by filtration; then transfer the filtered filtrate to the ring-closure kettle, and put the catalyst and toluene into the ring-closure kettle, raise the temperature to 100°C, and reflux the reaction 5 hours; then add water to the material after the aforementioned reflux to wash the impurities therein, transfer the aforementioned organic phase to a concentration tank for concentration; then after the aforementioned concentration of quantitative toluene, it is the toluene solution of benzofuranone; Finally, the benzofuranone i...

Embodiment 2

[0035] First put 800Kg of raw material o-chlorophenylacetic acid into a 2000L synthesis kettle, then add catalyst and liquid caustic soda to the aforementioned synthesis kettle, the concentration of liquid caustic soda is 40%, and heat up to 100°C for reaction. The catalyst is sodium ethoxide or quaternary ammonium salt One of them; secondly after the reaction of the aforementioned synthetic kettle is finished, the temperature of the synthetic kettle is cooled to room temperature; then the material in the aforementioned synthetic kettle cooled to room temperature is filtered, and the catalyst is recovered by filtration; then the aforementioned filtered filtrate Go to the ring-closing kettle, and put the catalyst and 300Kg toluene into the ring-closing kettle, raise the temperature to 100° C., and reflux for 5 hours. The catalyst is Raney Ni; The aforementioned organic phase is transferred to the concentration tank for concentration; then after the aforementioned concentration o...

Embodiment 3

[0038] First put 850Kg of raw material o-chlorophenylacetic acid into a 2000L synthesis kettle, then add catalyst and liquid caustic soda to the aforementioned synthesis kettle, the concentration of liquid caustic soda is 41%, heat up to 105°C for reaction, the catalyst is sodium ethoxide or quaternary ammonium salt One of them; secondly after the reaction of the aforementioned synthetic kettle is finished, the temperature of the synthetic kettle is cooled to room temperature; then the material in the aforementioned synthetic kettle cooled to room temperature is filtered, and the catalyst is recovered by filtration; then the aforementioned filtered filtrate Go to the ring-closing kettle, and put the catalyst and 350Kg toluene into the ring-closing kettle, raise the temperature to 105° C., and reflux for 6 hours. The catalyst is Raney Ni; The aforementioned organic phase is transferred to the concentration tank for concentration; then after the aforementioned concentration of qu...

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Abstract

The invention discloses a synthesis process of an azoxystrobin intermediate compound benzofuranone. The synthesis process comprises the following steps: 1) putting a raw material o-chlorophenylacetic acid into a synthesis kettle, adding a catalyst and liquid caustic soda into the synthesis kettle, and performing heating; 2) after the reaction in the synthesis kettle is completed, cooling the synthesis kettle; 3) filtering the material in the synthesis kettle cooled to room temperature, and recovering the catalyst through filtration; 4) transferring the filtrate into a cyclization kettle, inputting a catalyst and toluene, performing heating, and performing a reflux reaction; 5) adding water into the material after the reflux is completed, washing impurities therein, transferring the organic phase into a concentration kettle, and performing concentration; and 6) after the concentration is completed, obtaining a quantitative amount of toluene which is a benzofuranone toluene solution. The production process disclosed by the invention is relatively simple to operate and more friendly to the environment.

Description

technical field [0001] The invention relates to the technical field of oxadiazone processing, in particular to a synthesis process of benzofuranone, an intermediate of azoxystrobin. Background technique [0002] Azoxystrobin is a new high-efficiency, broad-spectrum, systemic fungicide. It can be used for stem and leaf spray, seed treatment, and soil treatment. [0003] Azoxystrobin is a new high-efficiency, broad-spectrum, systemic fungicide. It can be used for stem and leaf spray, seed treatment, and soil treatment. It is effective against almost all fungal diseases (Ascomycetes, Basidiomycetes, Oomycetes and Deuteromycetes), such as powdery mildew, rust, glumes, net spot, downy mildew, rice blast, etc. activity, and no cross-resistance with existing fungicides. It is safe for grains, rice, grapes, potatoes, vegetables, fruit trees and other crops. [0004] The intermediate of azoxystrobin is benzofuranone, its Chinese name: 2-chlorowarazone, Chinese alias: benzofurano...

Claims

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Application Information

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IPC IPC(8): C07D307/83
Inventor 黄金祥吴建平刘长庆戴玉婷黄显超杨亚明张军徐小兵朱张
Owner ANHUI GUANGXIN AGROCHEM
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