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Method for measuring free hemoglobin in blood bag by multi-position modulation of fluorescence excitation light source

A fluorescence excitation and hemoglobin technology, applied in fluorescence/phosphorescence, measurement devices, material excitation analysis, etc., can solve problems such as spectral nonlinearity, achieve strong measurement pertinence, solve non-destructive testing problems, and suppress nonlinear effects.

Inactive Publication Date: 2017-12-01
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, blood scattering will lead to nonlinearity of the spectrum and be affected by the background noise of the spectrum. In view of the above problems, this method proposes a method for measuring free hemoglobin in the blood bag by modulating the fluorescence excitation light source at multiple positions.

Method used

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  • Method for measuring free hemoglobin in blood bag by multi-position modulation of fluorescence excitation light source
  • Method for measuring free hemoglobin in blood bag by multi-position modulation of fluorescence excitation light source
  • Method for measuring free hemoglobin in blood bag by multi-position modulation of fluorescence excitation light source

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Embodiment 1

[0055] The embodiment of the present invention provides a method for measuring free hemoglobin in a blood bag with a multi-position modulated fluorescent excitation light source. The devices used are such as figure 2 As shown, it includes: a fluorescence excitation light source 1 , a blood bag 3 , a displacement platform 4 , a spectrum receiving device 5 and a modulation device 7 .

[0056] Wherein, ensure that the light exit port of the fluorescence excitation light source 1 and the incident slit of the spectrum receiving device 5 are close to the blood bag 3, the modulation device 7 modulates the fluorescence excitation light source 1 to make it emit a square wave light signal, and the fluorescence excitation light source 1 is at the first position a The blood sample in the blood bag 3 is excited, and the fluorescence spectrum is collected by the spectrum receiving device 5 . Then the fluorescence excitation light source 1 is controlled to move to the second position b by t...

Embodiment 2

[0065] The difference between the embodiment of the present invention and embodiment 1 is only that the fluorescence excitation light source 1 and the movement mode of the spectrum receiving device 5 are different, see the following description for details:

[0066] see image 3 To ensure that the light outlet of the fluorescence excitation light source 1 and the incident slit of the spectrum receiving device 5 are close to the blood bag 3, the modulation device 7 modulates the fluorescence excitation light source 1 so that it sends out a square wave light signal, and the fluorescence excitation light source 1 is connected to the blood bag 3 The blood sample is excited, and the fluorescence spectrum is collected at the first position a by the spectrum receiving device 5 . Then the spectrum receiving device 5 is controlled by the displacement platform 4 to move to the second position b, and the fluorescence spectrum at the second position b is collected; the spectrum receiving ...

Embodiment 3

[0071] During specific implementation, due to the limitation of the space structure, the situation that the fluorescence excitation light source 1 and the spectrum receiving device 5 cannot be close to the blood bag 3 may occur. , as the incident fiber 2 and the exit fiber 6 .

[0072] see Figure 4 , the modulation device 7 modulates the fluorescence excitation light source 1 to make it emit a square wave light signal, the fluorescence excitation light source 1 excites the blood sample in the blood bag 3 through the incident optical fiber 2, the fluorescence spectrum is collected by the spectrum receiving device 5 through the exit optical fiber 6, and the incident optical fiber 2 and the outgoing optical fiber 6 are respectively close to the blood bag 3, position a is the first position of the incident optical fiber 2, and the spectrum receiving device 5 collects the fluorescence spectrum at this position; then the incident optical fiber 2 is controlled to move to the second ...

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Abstract

The invention discloses a method for measuring free hemoglobin in a blood bag by multi-position modulation of a fluorescence excitation light source. According to the method, the fluorescence excitation light source is modulated by a modulation device, a light outlet of the fluorescence excitation light source and an entrance slit of a spectrum receiving device cling to a packaging bag, the fluorescence excitation light source excites the free hemoglobin to generate fluorescence, a displacement platform controls the fluorescence excitation light source to move to a plurality of positions, fluorescence spectrums are acquired by the spectrum receiving device, the time sequence of each wavelength in the fluorescence spectrums acquired at a plurality of positions is transformed to a frequency domain, fluorescence spectrums in the frequency domains are constructed by the aid of fundamental components with various wavelengths, the fluorescence spectrums are normalized and then compared with existing chemical analysis results, a mathematical model is built, fluorescence spectrums in frequency domains at a plurality of positions of a blood sample in an unknown blood bag are acquired by the same method and substituted into the mathematical model after normalization to obtain the content of the free hemoglobin.

Description

technical field [0001] The invention relates to the field of concentration analysis stoichiometry of complex spectral solutions, in particular to a method for measuring free hemoglobin in blood bags by modulating fluorescent excitation light sources at multiple positions. Background technique [0002] In the existing technology, the more mature technology is to detect the content of free hemoglobin in the blood bag through chemical testing, which has the outstanding advantage of high accuracy, but the chemical testing method needs to open the blood bag to take out the sample for testing, which cannot meet the needs of fast, Non-contact and pollution-free requirements. [0003] Through the study of fluorescence spectrum, it is found that it is also possible to detect the content of free hemoglobin in blood bags due to its non-contact, non-polluting, and highly targeted characteristics. [0004] However, blood scattering will lead to nonlinearity of the spectrum and be affect...

Claims

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Application Information

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IPC IPC(8): G01N21/64
CPCG01N21/6402G01N21/64G01N2021/6417
Inventor 林凌甄建芸王玉宇王艳军张盛昭罗永顺李刚
Owner TIANJIN UNIV
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