Compound electrolyte glucose injection and preparation method thereof

Abstract

The invention belongs to the field of a medicine preparation, and particularly relates to a compound electrolyte glucose injection and a preparation method thereof. The injection is prepared from the following ingredients in parts by weight: 2.5 to 5.5g of sodium chloride, 0.1 to 0.4g of magnesium chloride, 0.1 to 0.3g of calcium chloride, 1 to 3g of sodium acetate, 0.25 to 0.75g of L-malic acid, 20 to 30g of glucose, 4.5 to 6.5g of pH regulators, 10 to 100mg of antioxidizers and injection water for reaching the total volume of 1000ml. The invention also provides a preparation process of the sterile injection. The injection prepared by the method is colorless and clear; the side reactions are few; the medication adaptability and the safety of patients are high; the injection is applicable to supplementation of water, electrolyte and carbohydrate after the operation or injury, and is particularly applicable to the patients with low immunity and the patients with diseases of hyperammonemia, angiocardiopathy, anemia, uremia, hypertension, burn wound and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a compound electrolyte glucose injection and a preparation method thereof. Background technique [0002] The body's normal body fluid volume, osmotic pressure and electrolyte content are the basic guarantees for substance metabolism and normal function of various organs. Trauma, surgery, and many surgical diseases can lead to water and electrolyte disturbances in the body. Almost all patients in the perioperative period have varying degrees of water and electrolyte disturbances, which lead to abnormal physiological functions of the body, such as hypovolemic shock and hypovolemia caused by dehydration. If the arrhythmia caused by potassium is not corrected for a long time, it may directly affect the operation, leading to the delay of operation, poor prognosis after operation, and even life-threatening. The main purpose of intraoperative rehydration is to mai...

AI Technical Summary

Problems solved by technology

[0005] At present, the main problems existing in the existing compound electrolyte injection are: ① use sodium lactate, and sodium lactate is mainly metabolized in the liver. Difficult to completely convert to CO 2 and H 2 In addition, it is easy to accumulate lactic acid and cause lactic acidosis

At present, the compound electrolyte glucose injection of the same variety rarely distinguishes between potassium-containing and potassium-free preparations

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