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Composition for preventing and/or treating type I diabetes mellitus, as well as preparation method and application of composition

A composition and technology for diabetes, applied in the directions of drug combination, medical preparations containing active ingredients, metabolic diseases, etc., to achieve the effects of improving fasting blood sugar in mice, improving oral starch tolerance, and good drug efficacy

Inactive Publication Date: 2017-12-15
云南万绿生物股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no scientific compatibility of aloe vera and cinnamon for the treatment of type Ⅰ diabetes and related complications

Method used

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  • Composition for preventing and/or treating type I diabetes mellitus, as well as preparation method and application of composition
  • Composition for preventing and/or treating type I diabetes mellitus, as well as preparation method and application of composition
  • Composition for preventing and/or treating type I diabetes mellitus, as well as preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] The preparation method of aloe whole leaf freeze-dried powder comprises the following steps:

[0023] S101: Harvest fresh aloe, wash it, and squeeze the juice to obtain the whole aloe juice;

[0024] S102: adding cellulase and pectinase to the whole aloe juice for enzymolysis treatment to obtain an enzymolysis solution; filtering the enzymolysis solution with a filter membrane to collect the filtrate;

[0025] S103: The filtrate is freeze-dried and crushed to obtain freeze-dried aloe whole leaf powder.

[0026] The preparation method of cinnamon extract comprises the steps:

[0027] S201: remove the silt and sundries from the dry bark of Cinnamomum cassia Presl, and then pulverize it to obtain coarse cinnamon powder;

[0028] S202: Reflux extract the cinnamon coarse powder with an ethanol aqueous solution with a volume fraction of 80%. The mass of the ethanol aqueous solution is 10 times the mass of the cinnamon coarse powder. After reflux extraction for 2 hours, perf...

Embodiment 1

[0034] This embodiment provides a composition for preventing and / or treating type 1 diabetes. The raw material components include: 1.5 parts by weight of freeze-dried powder of whole leaves of aloe and 0.15 parts by weight of cinnamon extract;

[0035] Among them, the whole leaf freeze-dried powder of aloe is the whole leaf dry powder material obtained after the moisture is removed by freeze-drying process, wherein the content of aloin is not less than 2500.0mg / kg, the content of water is not higher than 8.0%, and the content of polysaccharide is not less than 2500.0mg / kg. less than 25000.0mg / kg, the content of O-acetyl group is not less than 15000.0mg / kg, the mass fraction of calcium is not less than 4.5%, and the mass fraction of magnesium is not less than 0.3%; Color dish, at 400nm wavelength, the measured absorbance is not higher than 2.50%;

[0036] The preparation method of aloe whole leaf freeze-dried powder comprises the following steps:

[0037] S101: Harvest fresh a...

Embodiment 2

[0047] This embodiment provides a composition for preventing and / or treating type 1 diabetes. The raw material components include: 1.0 parts by weight of freeze-dried powder of whole leaves of aloe vera and 0.20 parts by weight of cinnamon extract;

[0048] Among them, the whole leaf freeze-dried powder of aloe is the whole leaf dry powder material obtained after the moisture is removed by freeze-drying process, wherein the content of aloin is not less than 2500.0mg / kg, the content of water is not higher than 8.0%, and the content of polysaccharide is not less than 2500.0mg / kg. less than 25000.0mg / kg, the content of O-acetyl group is not less than 15000.0mg / kg, the mass fraction of calcium is not less than 4.5%, and the mass fraction of magnesium is not less than 0.3%; Color dish, at 400nm wavelength, the measured absorbance is not higher than 2.50%;

[0049] The preparation method of aloe whole leaf freeze-dried powder comprises the following steps:

[0050] S101: Harvest fr...

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Abstract

The invention relates to a composition for preventing and / or treating type I diabetes mellitus, as well as a preparation method and application of the composition. The composition is prepared from the following raw material components in parts by weight:1.0-2.0 parts of aloe whole-leaf lyophilized powder and 0.10-0.20 part of cinnamon extract. According to the method, the aloe whole-leaf lyophilized powder and cinnamon extract serving as raw material components are scientifically proportioned, the prepared composition can be used for improving the oral starch tolerance of mice, has a remarkable effect on improving fasting blood-glucose of mice, and has the efficacy of preventing and / or treating type I diabetes mellitus. According to the composition, raw material source is convenient, the process is stable, the compatibility is reasonable, and a theoretical foundation is provided for the development of hypoglycemic health foods and clinical application.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a composition for preventing and / or treating type I diabetes, a preparation method and application thereof. Background technique [0002] Aloe is an evergreen herb of Liliaceae and Aloe. It is native to the Mediterranean coast, Africa, and tropical America. It is also distributed in Yunnan, my country. Aloe vera is an ancient and traditional traditional Chinese medicine. No matter in traditional medicine or modern medicine, the medicinal value of aloe vera has been affirmed. This is clearly recorded in the early medical books and modern pharmacopoeias of our country. In recent years, aloe has been widely used in cosmetics, food, health products and other fields. Cinnamon is the dry bark and rough bark of Cinnamomum cassia Presl, an evergreen tree plant of Lauraceae, mainly produced in Guangdong, Guangxi and other places. Split the bark before the Great Summer Festi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/886A61P3/10
CPCA61K36/54A61K36/886A61K36/896A61K2236/19A61K2236/31A61K2236/333A61K2236/51A61K2300/00
Inventor 孙秋
Owner 云南万绿生物股份有限公司
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