Efficient and safe chitosan derivative-based disinfection liquid and preparation method thereof

A chitosan derivative and disinfectant technology, applied in the field of disinfectant, can solve the problems of surgical wound infiltration, human body entering blood, mucosal irritation and the like

Active Publication Date: 2017-12-22
HAERBIN EN JOO BIOTECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And it has obvious stimulating effect on the mucous membrane during normal use, and a few people have allergic reactions, and there is a risk of infiltration into the human body and blood when used on surgical wounds

Method used

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  • Efficient and safe chitosan derivative-based disinfection liquid and preparation method thereof
  • Efficient and safe chitosan derivative-based disinfection liquid and preparation method thereof
  • Efficient and safe chitosan derivative-based disinfection liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] Prepare and synthesize the material described in formula (1) of the present invention:

[0090] Take by weighing 0.1 gram of chitosan and join in 100 milliliters of deionized water, mechanically stir at room temperature for half an hour, so that chitosan dissolves completely, thereby obtain the homogeneous solution that mass volume percent concentration is 0.1%; Slowly add thiourea trioxide into the system, the molar ratio of thiourea trioxide and chitosan is 10:1, the feeding time is 30 minutes, and the reaction at room temperature is kept for 60 minutes; A mixed solution of amino acid, N-hydroxysuccinimide (NHS) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC·HCl) (solvent: 30mmol / L of 2-(N-morpholino)ethanesulfonic acid (MES) buffer solution) 20ml was added to the above-mentioned reaction solution, and the stirring reaction was continued at room temperature for 48 hours, wherein chitosan, arginine, NHS, EDC The molar ratio of the solution is 50...

Embodiment 2

[0094] Prepare and synthesize the material described in formula (2) of the present invention:

[0095] Weigh 0.1g carboxymethyl chitosan (the number average molecular weight is 2×10 5 Da, the degree of carboxymethyl substitution is 100%, and the degree of deacetylation is 100%), add 100mL deionized water, and mechanically stir evenly at room temperature, so that carboxymethyl chitosan is completely dissolved, thereby obtaining a mass volume percent concentration of 0.1% solution; weigh 2,3-epoxypropyltrimethylammonium chloride, dissolve in 50mL deionized water, and stir mechanically at room temperature; Ammonium chloride solution was slowly added to the carboxymethyl chitosan solution in 3 times, and the feeding time was 4 hours, and then stirred at constant temperature for 4 hours; Adjust the pH value of the solution to 5.0 and the salt concentration to 0.01M to obtain solution S1; weigh NHS and EDC (molar ratio is 1:10), dissolve in 30mL 0.01M pH 5.0MES / HCl buffer solution ...

Embodiment 3

[0099] Prepare and synthesize the material described in formula (3) of the present invention:

[0100] Take by weighing 0.35g carboxymethyl chitosan (the number average molecular weight is 2×10 5 Da, the degree of carboxymethyl substitution is 100%, and the degree of deacetylation is 95%), add 35mL deionized water, mechanically stir evenly at room temperature, carboxymethyl chitosan is completely dissolved, thereby obtaining the mass volume percentage concentration is 1% solution; weigh NHS and EDC (molar ratio is 1:1), dissolve in 15mL 0.01M pH5.0MES / HCl buffer solution to obtain a catalyst solution; weigh arginine and add it to the catalyst solution for activation, and stir at room temperature for 1 hour; The arginine activation solution was poured into the carboxymethyl chitosan solution for 3 times, and reacted for 24 hours under stirring conditions at 45°C; Terminate the reaction; the reaction product was dialyzed in 1L of deionized water, the molecular weight cut-off of t...

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Abstract

The invention discloses an efficient and safe chitosan derivative-based disinfection liquid and a preparation method thereof, wherein the components of the formula comprise 0.05-10 g of a chitosan derivative, and 100 ml of sterilized deionized water. According to the present invention, the efficient and safe chitosan derivative-based disinfection liquid has characteristics of exact treatment effect, no toxic-side effect and no irritating to skin, can be used as the sterilization disinfection agent in the medical treatment, can be used for disinfecting skin and mucous membrane, can be used for treating scald, trichomonas vaginitis, fungal vaginitis, skin mold infections, fungal infections and the like, can further be used for burn injury, frostbite, knife wounds, abrasions, contusion and other general trauma, and can be used for pre-surgery disinfection, disinfection of other skins, disinfection of skins in various injection sites, equipment soaking disinfection, disinfection before vaginal surgery, and the like.

Description

technical field [0001] The invention relates to a disinfectant. More specifically, it relates to a highly efficient and safe chitosan derivative-based disinfectant and a preparation method thereof. Background technique [0002] Sanitizer is a liquid disinfectant. An ideal disinfectant should have a broad bactericidal spectrum, strong bactericidal ability, fast action speed, good stability, low toxicity, low corrosion, and low irritation (should be non-toxic, non-residual, non-corrosive, and non-irritating) and be easily soluble in Water, safe for people and animals, cheap and easy to get, low degree of environmental pollution, etc. At present, most of the disinfectants for clinical external use are western medicine preparations. Although the disinfection effect is good, long-term use can produce certain irritation and side effects. [0003] At present, the disinfectant widely used in hospitals is mainly iodophor, which has a broad-spectrum bactericidal effect and can kill...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61P31/02A61P31/04A61P31/10A01N47/44A01N43/16A01P1/00A01P3/00C08B37/08
CPCA01N43/16A01N47/44A61K31/722C08B37/003A61P31/02A61P31/04A61P31/10Y02A50/30
Inventor 吕振东牛忠伟蒋士冬
Owner HAERBIN EN JOO BIOTECH CO LTD
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