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Novel pH sensitive type hydrogel and preparation method and application thereof

A sensitive hydrogel, a new type of technology, used in pharmaceutical formulations, medical preparations with inactive ingredients, ointment delivery, etc., can solve problems such as limitations, achieve high swelling rate, good biocompatibility, improve swelling and The effect of de-swelling kinetics

Active Publication Date: 2018-01-05
HUNAN QIWEI TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the pH sensitive range of the hydrogel of the invention, it is limited as its possibility of administration through the gastrointestinal tract.

Method used

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  • Novel pH sensitive type hydrogel and preparation method and application thereof
  • Novel pH sensitive type hydrogel and preparation method and application thereof

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Effect test

Embodiment 1

[0028] The novel pH-sensitive hydrogel of the present invention is modified by vinyl-modified carboxymethyl chitosan, itaconic acid, maleic anhydride, diethylaminoethyl methacrylate, and N-isopropyl propylene The amide and crosslinking agent are comonomers, which are prepared by a specific aqueous free radical polymerization method. They have the characteristics of pH sensitivity, fast response, and good biocompatibility. The preparation method is as follows:

[0029] a) Preparation of vinyl-modified carboxymethyl chitosan: add 20 parts of anionic carboxymethyl chitosan, 2 parts of triethylamine, and 30 parts of dimethyl sulfoxide into the reactor, stir to dissolve and heat up At 50°C, add 10 parts of glycidyl methacrylate dropwise, and react at 50°C for 5 hours; then add methanol to dissolve and dilute, add acetone for precipitation, filter precipitation, repeat methanol dissolution and dilution, acetone precipitation, and vacuum dry the precipitation. The preparation of vinyl m...

Embodiment 2

[0032] The novel pH-sensitive hydrogel of the present invention is modified by vinyl-modified carboxymethyl chitosan, itaconic acid, maleic anhydride, diethylaminoethyl methacrylate, and N-isopropyl propylene The amide and crosslinking agent are comonomers, which are prepared by a specific aqueous free radical polymerization method. They have the characteristics of pH sensitivity, fast response, and good biocompatibility. The preparation method is as follows:

[0033] a) Preparation of vinyl modified carboxymethyl chitosan: add 10 parts of carboxymethyl chitosan, 5 parts of 2,4,6-tris(dimethylaminomethyl)phenol, and 30 parts of DMF to the reaction In the kettle, stir to dissolve and heat to 60°C, add 10 parts of glycidyl methacrylate drop by drop, and react at 60°C for 10 hours; then add methanol to dissolve and dilute, add acetone for precipitation, suction filter precipitation, repeat methanol dissolution and dilution, The preparation of vinyl-modified carboxymethyl chitosan ca...

Embodiment 3

[0036] The novel pH-sensitive hydrogel of the present invention is modified by vinyl-modified carboxymethyl chitosan, itaconic acid, maleic anhydride, diethylaminoethyl methacrylate, and N-isopropyl propylene The amide and crosslinking agent are comonomers, which are prepared by a specific aqueous free radical polymerization method. They have the characteristics of pH sensitivity, fast response, and good biocompatibility. The preparation method is as follows:

[0037] a) Preparation of vinyl-modified carboxymethyl chitosan: add 18 parts of carboxymethyl chitosan, 4 parts of N,N-dimethyl-p-aniline, and 50 parts of DMF into the reactor, stir and dissolve evenly Heat to 40°C, add 10 parts of glycidyl methacrylate dropwise, and react for 8 hours at 40°C; then add methanol to dissolve and dilute, add acetone for precipitation, suction filter precipitation, repeat methanol dissolution and dilution, acetone precipitation, vacuum dry precipitation The preparation of vinyl modified carbox...

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Abstract

The invention relates to novel pH sensitive type hydrogel and a preparation method and an application thereof. According to the hydrogel, selected pH response main polymer monomer raw materials of carboxymethyl chitosan and itaconic acid both come from natural product chemical compounds and are water-based environmentally friendly and good in biocompatibility; the polyvinyl modified carboxymethylchitosan and polyitaconic acid in the hydrogel are subjected to carboxyl ionization at a high pH value, meanwhile the polyvinyl modified carboxymethyl chitosan and poly N-isopropylacrylamide are subjected to amino absorption hydrogen ion ionization at a low pH value, and due to existence of different polymer units, the hydrogel has pH sensitivity. The hydrogel has higher swelling ratio at relatively mild pH and has low swelling ratio at relatively drastic pH so that the hydrogel can be used for drug release, achieves effectiveness of drug administration through the gastrointestinal tract and has wide application prospects.

Description

Technical field [0001] The invention relates to a novel pH-sensitive hydrogel, a preparation method and application thereof, and belongs to the technical field of hydrogels. technical background [0002] Smart hydrogel is a type of hydrogel that can respond to changes in external stimuli such as temperature, pH, solvent, ion concentration, light, electric field, and magnetic field. This feature makes intelligent hydrogels have good application prospects in tissue engineering, biological separation, immobilized enzymes and controlled release of drugs, among which pH-sensitive gels have been studied more. [0003] The so-called pH-sensitive gel is a polymer hydrogel whose volume changes with the pH of the environment. This type of gel structure has groups that can be dissociated into ions (such as carboxyl, sulfonic acid, or amino, etc.), which capture or release protons according to changes in environmental pH. When the external pH changes, these dissociable groups The clusters wi...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08F290/00C08F222/02C08F222/06C08F220/54C08F220/34C08B37/08
CPCA61K9/06A61K47/36C08B37/003C08F290/00C08J3/075C08J2351/02C08F222/02C08F222/06C08F220/54C08F220/34
Inventor 李丽娟
Owner HUNAN QIWEI TECH CO LTD
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