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N-aralkylcarbonyldiamine compounds and personal care compositions comprising the same

一种芳烷基羰基二胺化合物、化合物的技术，应用在个人护理组合物领域，能够解决未被认可化妆品等问题

Active Publication Date: 2018-01-05
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Also, none of these compositions are approved for use as cosmetics for personal care benefits

Method used

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  • N-aralkylcarbonyldiamine compounds and personal care compositions comprising the same
  • N-aralkylcarbonyldiamine compounds and personal care compositions comprising the same
  • N-aralkylcarbonyldiamine compounds and personal care compositions comprising the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0105] Representative N-aralkylcarbonyldiamines of structure I within the scope of the invention were investigated for their inhibition of the muscarinic 3 receptor and their ability to induce cell proliferation in living skin equivalents.

[0106] The following results show that the compounds included in the present invention effectively inhibit the muscarinic 3 receptor (Table 1). Specifically, IC 50 Compounds with a value (defined as the concentration of compound that inhibits the muscarinic receptor response to 50% of its maximum response) below 10 [mu]M provide this inhibition. Additionally, based on at least one IC 50 Testing other muscarinic 3 receptor antagonists at the 10 μM level, applicants have noted that this concentration provides enhanced cell proliferation. As can be seen, the ICs of all novel compounds of the invention 50 The values ​​are all well below 10 μM.

[0107] Table 1

[0108]

[0109] The following results show that representative N-aralkylca...

Embodiment 6

[0113] A lotion according to the invention having the formulation outlined in Table 3 below is exemplified herein. The formula is packaged in a standard polypropylene bottle with a screw cap. A label around the outside of the bottle states the effectiveness of the composition in combating the signs of aging, including the removal of fine lines and wrinkles.

[0114] table 3

[0115]

[0116]

Embodiment 7

[0118] The water-in-oil topical liquid cosmetic foundations according to the present invention are described in Table 4 below. This foundation is delivered in a glass screw cap capped bottle. Bottles were placed in outer cartons. Inside the carton are included instructions for applying the foundation to the face to achieve improvements in the signs of aging, including enhanced radiance.

[0119] Table 4

[0120]

[0121]

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PUM

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Abstract

A personal care composition comprising N-aralkylcarbonyldiamines. When such compounds are used in personal care compositions, they have been unexpectedly shown to enhance cell proliferation and epidermal thickness, traits associated with younger, healthy looking skin.

Description

technical field [0001] The present invention relates to novel N-arylalkylcarbonyldiamine compounds and personal care compositions comprising one or more of said compounds. Background technique [0002] Youthful looking and healthy skin is a desired attribute worldwide and the market for cosmetics that can improve the appearance of our skin is large and growing. As we age, our natural ability to maintain youthful-looking, healthy skin diminishes, and as a result, our skin's appearance changes in response to biological processes occurring at the cellular level within the skin. Various cosmetic ingredients improve the health and appearance of the skin by intervening in specific pathways to regulate these processes at the skin surface. Numerous examples of the way cosmetic ingredients can modify appearance through this type of intervention are well documented. [0003] Increased cell proliferation and migration and epidermal thickness are some of the features associated with a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C233/40C07C235/34A61K8/42A61Q19/00A61Q19/08
CPCA61K8/42A61Q19/08C07C233/40C07C235/34C07C2601/08C07C2601/14C07C2601/16
Inventor J·G·罗萨李建明D·马雷罗J·E·阿达穆斯S·维拉莫拉
Owner UNILEVER IP HLDG BV
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