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Ion isolation apparatus used for ion trap mass spectrometer and isolation method

A technology for ion trap mass spectrometers and isolation devices, which is applied in the field of ion isolation devices for ion trap mass spectrometers, can solve the problems of band frequency component loss, affecting mass isolation performance, reducing device isolation resolution, etc., and achieves the goal of improving isolation resolution Effect

Active Publication Date: 2018-01-16
CHINA INNOVATION INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Since the SWIFT signal is derived from the inverse Fourier transform, its algorithm cannot be infinitely long in time, and is limited by the frequency of digital-to-analog conversion, which may easily cause the loss of frequency components in the frequency band
When the suppression frequency bandwidth of SWIFT is set to be small, the isolation resolution of the device can be increased, but the loss of target ions is very large in this case; when the suppression frequency bandwidth of SWIFT is set to be large, the target ion Ions of adjacent frequencies also appear, thereby reducing the isolation resolution of the device, which shows that the conventional SWIFT isolation method is not accurate in isolating ions
[0006] In particular, during the analysis process, when there is a strong interfering ion in the ion trap, it will seriously affect the performance of mass isolation. At this time, only applying such a SWIFT signal cannot filter out this strong interfering ion

Method used

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  • Ion isolation apparatus used for ion trap mass spectrometer and isolation method
  • Ion isolation apparatus used for ion trap mass spectrometer and isolation method
  • Ion isolation apparatus used for ion trap mass spectrometer and isolation method

Examples

Experimental program
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Effect test

Embodiment 1

[0074] The structure of a high-resolution ion isolation device is as follows image 3shown. The whole device contains three sets of transformer coils, wherein 303 is the primary coil of the first set of transformers, 304 is the secondary coil of the first set of transformers, and the input end of the secondary coil is connected to the original SWIFT signal (that is, the first signal occurs The signal output by the device), the output end is connected to the input end of the secondary coil of the second group of transformers, and 302 is a sine wave signal of a frequency value that needs to be coupled into the original SWIFT signal (that is, the signal output by the second signal generator) , 305 is a sine wave signal of another frequency value that needs to be coupled into the original SWIFT signal (that is, the signal output by the third signal generator), 306 is the primary coil of the second group of transformers, and 307 is the secondary of the second group of transformers ...

Embodiment 2

[0079] refer to Figure 4 Shown is the structure of another high-resolution ion isolation device. The difference between this device and Embodiment 1 is that the positions of the two signal generators are exchanged. Compared with Embodiment 1, the positions of SIN1 and SWIFT signals are exchanged. 403 is the primary coil of the first group of transformers, 404 is the secondary coil of the first group of transformers, the input end of the secondary coil is connected with a sine wave signal of a specific frequency value (ie the signal output by the first signal generator), The output end is connected to the input end of the secondary coil of the second group of signal generators, 402 is the original SWIFT signal that needs to be coupled in, and 401 is the signal output by the first signal generator (that is, a sine wave signal with a specific frequency value) , the subsequent connection methods are similar to those in Embodiment 1, and will not be repeated here. This device ca...

Embodiment 3

[0081] refer to Figure 5 Shown is the structure of another high-resolution ion isolation device. The difference between this device and Embodiment 1 is that two sets of transformers are added, and compared with Embodiment 1, it has a symmetrical structure. 509 is the primary coil of the newly added first group of transformers, both ends of the primary coil are grounded, 510 is the secondary coil of the newly added first group of transformers, the input end of the secondary coil is grounded, and 512 is the newly added second group of transformers The secondary coil, the input terminal of the secondary coil is connected to the output terminal of the secondary coil of the newly added first group of transformers, the output terminal of the secondary coil is connected to the secondary coil of the third transformer described in Embodiment 1 One input terminal (the input terminal described in Embodiment 1 is grounded), 511 is the primary coil of the newly added second group of trans...

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Abstract

The invention discloses an ion isolation apparatus used for an ion trap mass spectrometer and a method. The apparatus comprises at least 3 signal generators and a plurality of transformers, wherein one signal generator is a SWIFT signal generator used for resonance excitation in a mass spectrometric analysis process, the other signal generators are sine wave generators, the output frequency of thesine wave generators corresponds to the Notch cut-off frequency of SWIFT signals, and the transformers are used for coupling signals generated by the SWIFT signal generator and signals generated by the sine wave signal generators and applying the coupled signals to a response electrode of an ion trap. According to the apparatus and the method, high mass isolation resolution and efficiency can besimultaneously realized, the loss of target parent ions is reduced, and the performance of a multistage mass spectrometric analysis of the ion trap can be integrally enhanced.

Description

technical field [0001] The invention belongs to the technical field of analytical instruments, and in particular relates to an ion isolation device and an isolation method for an ion trap mass spectrometer. Background technique [0002] Mass spectrometer is a kind of chemical analysis instrument, which is widely used in the fields of food safety, life science, medicine and pharmaceutical, environmental monitoring and public safety. Mass spectrometers can be classified into ion trap mass spectrometers, quadrupole mass spectrometers, magnetic mass spectrometers, Fourier transform-ion cyclotron resonance mass spectrometers, and time-of-flight mass spectrometers. [0003] Among the many types of mass spectrometers, ion trap mass spectrometers have unique advantages, which can realize multi-stage mass spectrometry analysis in a single ion trap, further improving the ability of qualitative and structural analysis of substances. The process of ion trap to achieve multi-stage mass ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/26H01J49/02
Inventor 李晓旭钱洁张曙光吴海燕张礼朋
Owner CHINA INNOVATION INSTR CO LTD
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