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A kind of antibacterial medicinal liquid for intravenous indwelling needle and preparation method thereof
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A technology of intravenous indwelling needles and antibacterial liquid, which is applied in the field of medicine, can solve the problems of poor antibacterial properties and easy oxidation, and achieve the effects of long effective duration, preventing oxidation, and inhibiting bacteria
Active Publication Date: 2020-06-12
佳康医用器材(青岛)有限公司
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[0003] The object of the present invention is to provide a kind of antibacterial liquid for intravenous indwelling needles, and provide the antibacterial drug Preparation method of liquid and indwelling needle containing the antibacterial liquid
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Embodiment 1
[0019] An antibacterial drug solution for intravenous indwelling needles, which comprises the following components in parts by weight of raw materials: 87.99 parts of methanol with a concentration of 85%, 0.5 parts of sodium citrate, 0.5 parts of sodium ascorbate, 1 part of butyl acetate, hydrochloric acid 5.5 parts of minocycline, 4.5 parts of ciprofloxacin, and 0.01 part of sodium dodecylsulfonate. Wherein minocycline hydrochloride:ciprofloxacin=1.22:1.
[0020] Use this antiseptic solution to treat the tubing in the intravenous indwelling needle:
[0021] 1) Put the tube body in ethanol and ultrasonically clean it for 10 minutes, then ultrasonically clean it in pure water for 15 minutes, take it out, and dry it for later use;
[0022] 2) Dissolve 87.99 parts of methanol with a concentration of 85%, 0.5 part of sodium citrate and 0.5 part of sodium ascorbate at 30-50°C for 10-30 minutes in parts by weight of raw materials, add the tube obtained in step 1), and add butyl ace...
Embodiment 2
[0042] Embodiment 2: antibacterial test
[0043]Antibacterial tests were carried out on the intravenous indwelling needle tubes obtained in Example 1 and Comparative Examples 1 to 6 by using the antibacterial ring test method: insert a small section (5 mm) of the tube body into a medium plate, cultivate for 18 to 24 hours, and measure the antibacterial ring with a vernier caliper The larger the diameter of the antibacterial ring, the better the antibacterial effect. The test results are shown in Table 1.
[0044] Table 1 Antibacterial test results for drug-resistant Staphylococcus aureus
[0045]
[0046] According to the data in Table 1, the antibacterial liquid used in the present invention, its antibacterial ring diameter can still reach 8.46mm after 29 days, its effect is obviously better than the comparative example 6 that selects rifampicin and chlorhexidine as antibacterial drugs, It is also obviously better than selecting minocycline hydrochloride and ciprofloxacin...
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Abstract
The invention discloses an antibacterial drug liquid for a venous indwelling needle. The antibacterial drug liquid comprises, by weight, 87.99 parts of methanol having a concentration of 85%, 0.5 parts of sodium citrate, 0.5 parts of an antioxidant, 1 part of a penetration enhancer, 5.5 parts of minocycline hydrochloride, 4.5 parts of ciprofloxacin and 0.01 parts of sodium dodecyl sulfonate. The antibacterial drug liquid utilizes synergism of minocycline hydrochloride and ciprofloxacin. The best antibacterial ratio is obtained by a test. The antibacterial drug liquid can effectively inhibit various bacteria and especially inhibit drug-resistant staphylococcus aureus. The penetration enhancer realizes deep penetration of a drug in an indwelling needle conduit and solves the problem that thecommon drug coating conduit only stays on the surface and causes poor drug penetration, poor content and poor antibacterial effects. The antioxidant can effectively prevent the oxidation of the antibacterial liquid so that the effective duration of the antibacterial property is longer.
Description
technical field [0001] The invention relates to the field of medicine, in particular to an antibacterial liquid for indwelling needles. Background technique [0002] Venous indwelling needle is a medical device used for indwelling intravenous infusion, which is mainly used in clinical venipuncture for medicine and nutrition supply for patients. Some traditional antibacterial intravenous indwelling needles are prepared by mixing antibacterial drugs and plastic masterbatches and then extruded. The high temperature in the extrusion process will definitely damage the antibacterial drugs, thereby greatly reducing their antibacterial effects; Anti-infection reagents containing silver ions, and anti-infection reagents containing silver ions have the problem of clinical allergy to patients; Oxidation phenomenon and insufficient penetration of antibacterial drugs into the tube body lead to problems such as insufficient antibacterial performance, inability to perform for a long time,...
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