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A kind of medicinal composition containing Angelica dahurica and its application

A composition and technology of Angelica dahurica extract are applied in the directions of pharmaceutical combinations, medical preparations containing active ingredients, active ingredients of hydroxyl compounds, etc. Less, more potent and simple to prepare

Active Publication Date: 2021-07-06
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs have many shortcomings, such as low effective rate, delayed onset time, many adverse reactions, etc.

Method used

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  • A kind of medicinal composition containing Angelica dahurica and its application
  • A kind of medicinal composition containing Angelica dahurica and its application
  • A kind of medicinal composition containing Angelica dahurica and its application

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0126] Preparation Example 1: Preparation of Radix Angelicae Radix Extract (extract)

[0127] 2 kg of Angelica dahurica (root medicine) was crushed, soaked in 85% ethanol solution (1:10, w:v) for 24 hours, then ultrasonically extracted for 1 hour, during which time it was shaken every 15 minutes, and the extraction temperature was 25°C. Collect the first extract. Under the same conditions, the second and third extractions were carried out respectively from the solid medicinal dregs. Combine the 3 extracts and discard the dregs.

[0128] The combined extracts were concentrated under reduced pressure to obtain 150 g of extract.

[0129] Extraction rate = 150g / 2000g = 7.5%.

preparation example 2

[0130] Preparation Example 2: Preparation of Angelica Radix Extract-borneol composition

[0131] The extraction method of Angelica dahurica extract is the same as the previous preparation example 1.

[0132] Grind the borneol into a powder, mix it with the extract of Angelica dahurica before use and dissolve it in 0.5% CMC-Na, and make a prescription of borneol: Angelica dahurica according to the mass ratio of medicinal materials 1:180.

preparation example 3

[0133] Preparation example 3: Preparation of Angelica dahurica-Chuanxiong extract (extract)

[0134] Angelica dahurica 1kg, Chuanxiong 0.6kg, mixed and crushed, soaked in 85% ethanol (1:10, w:v) for 24 hours. Then ultrasonically extract for 1 hour, shake well once every 15 minutes, and extract at 25°C. Collect the first extract. Under the same conditions, the second and third extractions were carried out respectively from the solid medicinal residues. Combine 3 times of ultrasonic ethanol extracts, and discard drug residues.

[0135] The combined extracts were concentrated under reduced pressure to obtain 111 g of extract.

[0136] Extraction rate=111g / 1600g=6.9%.

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Abstract

The invention belongs to the field of traditional Chinese medicine, and relates to a medicinal composition containing Angelica dahurica and its application. The present invention also relates to the new application of Angelica dahurica. Specifically, the present invention relates to a pharmaceutical composition comprising an effective amount of any one selected from the following items (1) to (8): (1) Angelica dahurica, (2) Angelica dahurica and Borneol, (3) Angelica dahurica and Chuanxiong, (4) Angelica dahurica, Borneolum and Chuanxiong, (5) Angelica dahurica extract, (6) Angelica dahurica extract and Borneolum, (7) Angelica dahurica and Chuanxiong extract, and (8) Angelica and Chuanxiong extract and Borneolum; optional Preferably, the pharmaceutical composition further comprises one or more pharmaceutically acceptable excipients. The present invention can effectively treat or prevent depression.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a medicinal composition containing Angelica dahurica and its application. The present invention also relates to the new application of Angelica dahurica. Background technique [0002] Depression is a disease that has attracted increasing attention. It is clinically characterized by significant and persistent low mood, slow thinking and reduced activity. The low mood is not commensurate with the situation. In severe cases, suicidal thoughts and behaviors may appear. The specific etiology and pathogenesis of depression are still unclear. [0003] Drug intervention is the main method for the treatment of depression. The commonly used antidepressants in clinic mainly include: 5-HT reuptake inhibitors (SSRIs), 5-HT / NE dual reuptake inhibitors (SNRIs), tricyclic antidepressants drugs (TCAs), and monoamine oxidase inhibitors (MAOIs), among others. However, these drugs have m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/232A61K36/236A61P25/24A61K31/045
Inventor 张有志薛瑞李云峰丁振春张亭亭
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A