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Medicine for treating patients with obesity-related hypertension and preparation method thereof

A technology for obese hypertension and drugs, which is applied in the direction of medical formula, drug combination, drug delivery, etc., to achieve the effect of reducing contraindications, strengthening the antihypertensive effect, and significant curative effect

Inactive Publication Date: 2018-02-09
郭裴哲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Obese hypertensive patients need to lose weight and lower blood pressure. Currently, there is no effective drug for obese hypertensive patients on the market. Therefore, finding effective intervention drugs has very important theoretical significance and application value

Method used

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  • Medicine for treating patients with obesity-related hypertension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] In terms of parts by weight, 10 parts of nifedipine, 5 parts of metoprolol, and 15 parts of orlistat were taken, and clinically acceptable auxiliary materials were used to prepare respectively nifedipine sustained-release pellets, metoprolol sustained-release pellets, and metoprolol sustained-release pellets. Release pellets, orlistat sustained-release pellets, and then mix them into capsules to obtain drug capsules.

Embodiment 2

[0018] In terms of parts by weight, 8 parts of nifedipine, 4 parts of metoprolol, and 10 parts of orlistat were taken, and clinically acceptable auxiliary materials were used to prepare respectively nifedipine sustained-release pellets, metoprolol sustained-release pellets, and metoprolol sustained-release pellets. Release pellets, orlistat sustained-release pellets, and then mix them into capsules to obtain drug capsules.

experiment example

[0028] 600 obese hypertensive patients were randomly divided into 6 groups, wherein the first group took the drug capsules prepared in Example 1, the second group took the drug capsules prepared in Example 2, and the third group took the drug capsules prepared in Comparative Example 1 , the fourth group took the drug capsules prepared in Comparative Example 2, the fifth group took the drug capsules prepared in Comparative Example 3, and the sixth group took the drug capsules prepared in Comparative Example 4. Each patient took the same dosage every day, which was 2 capsules. After taking it for 12 months, measure the patient's body weight and blood pressure, the results are shown in Table 1:

[0029] Table 1

[0030]

[0031] It can be seen from Table 1 that the drug capsules composed of nifedipine, metoprolol and orlistat can treat obesity and hypertension at the same time, which is not only better than using antihypertensive drugs or weight-loss drugs alone, but also comp...

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Abstract

The invention relates to a medicine for treating patients with obesity-related hypertension and a preparation method thereof. Effective active ingredients of the medicine are nifedipine, metoprolol and orlistat. The orlistat, the nifedipine and the metoprolol creatively prepares into the medicine, exerting the effect of the orlistat in losing weight and the effect of the nifedipine and the metoprolol in lowering blood pressure, and through a lot of experiments, the remarkable therapeutic effect of the medicine prepared from the nifedipine, the metoprolol and the orlistat in treating obesity-related hypertension is discovered.

Description

technical field [0001] The invention relates to a compound western medicine, in particular to a medicine for treating obese hypertensive patients and a preparation method thereof. Background technique [0002] Obesity-induced hypertension is a common clinical problem. Epidemiological studies have shown that obesity is one of the important risk factors for hypertension. The relative risk of hypertension increases significantly with the increase of body mass index. At the same time, obesity and high Blood pressure and both are important risk factors for cardiovascular disease, and when the two exist at the same time, the risk factors are more serious. According to statistics, the incidence of hypertension is 10-15%, of which 10-40% is accompanied by obesity or overweight. The incidence of hypertension in obese people is significantly higher than that in non-obese people, which is a fact confirmed by clinical observation. [0003] Obese hypertensive patients need to lose weig...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61K9/52A61P9/12A61K31/138A61K31/365
CPCA61K31/4422A61K9/5084A61K31/138A61K31/365A61K2300/00
Inventor 郭裴哲
Owner 郭裴哲