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Method for quantitative analysis of sucralose content through combination of mid-infrared spectroscopy and vector angle

A technology of sucralose and infrared spectroscopy, applied in the field of quantitative analysis of compound infrared spectroscopy, to achieve rapid and accurate determination, independent of spectral characteristic response, and low detection limit

Active Publication Date: 2018-02-23
JK SUCRALOSE
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  • Application Information

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Problems solved by technology

[0003] The infrared light in the infrared transmission spectrum region can penetrate up to 30mm in the sample. Compared with the diffuse reflectance technique (Diffuse Reflectance Technique), the obtained spectral information is more abundant, but because Christiansen (Christiansen, 1884) cannot avoid The effect exists, and it is also severely restricted by information superposition. There are still few reports on quantitative application of infrared transmission spectroscopy using traditional KBr tablet and coating methods.

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  • Method for quantitative analysis of sucralose content through combination of mid-infrared spectroscopy and vector angle
  • Method for quantitative analysis of sucralose content through combination of mid-infrared spectroscopy and vector angle
  • Method for quantitative analysis of sucralose content through combination of mid-infrared spectroscopy and vector angle

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experiment example

[0045] Experimental Instruments and Reagents

[0046] Frontier Fourier Transform Infrared Spectrometer (Perkin Elmer, USA), Agilent1200 High Performance Liquid Chromatography (Agilent, USA), WS70-1 Far Infrared Fast Drying Oven, CP214 Electronic Analytical Balance.

[0047] Sucralose (sucralose) reference substance (99.99%, by HPLC), sucralose-6-ethyl ester (sucralose-6-ethyl ester) reference substance (96.5%, by HPLC), KBr (AR) , deacylated sample (self-made, containing sucralose, sucralose-6-ethyl ester, a small amount of other by-products such as methyl acetate, considered here as a multi-component sample)

[0048] Serial sample preparation

[0049] Prepare the KBr tablet of the sucralose reference substance and the sucralose-6-ethyl ester reference substance: Accurately weigh the reference substance and add KBr, mix well and then compress the tablet, the numbers are S 0 , S 10 ;

[0050] Prepare the KBr tablet of the two-component sample: the sucralose-6-ethyl ester and ...

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Abstract

The invention discloses a method for quantitative analysis of sucralose content through combination of a mid-infrared spectroscopy and a vector angle. The method comprises preparing KBr tablets of a sucralose reference substance, a sucralose-6-ethyl ester reference substance, a two-component mixed sample and a deacylated sample, acquiring infrared spectrum data, acquiring mid-infrared transmittedspectrums of the samples obtained by the step 1 under conditions of 450-4000cm<-1>, resolution 4cm<-1> and data interval of 1cm<-1> and carrying out data processing. The method can quickly and accurately determine the product content of the sucralose synthesis process. The method is free of sample pretreatment, is simple, is free of big data modeling and has the characteristics of independent of spectral response, low detection limit and wide application range.

Description

technical field [0001] The invention relates to the field of infrared spectrum quantitative analysis of compounds, in particular to a method for quantitatively analyzing the content of sucralose by combining mid-infrared spectrum with vector angles. Background technique [0002] Infrared spectroscopy, the most commonly used method for molecular characterization, is generally considered to have limited quantitative capabilities. Since the infrared spectrum is generated by the vibrational absorption of molecules in the infrared region, it has disadvantages such as weak energy, poor interpretation of the spectrum, and high detection limit, making direct quantitative analysis difficult. In recent years, with the popularization of attenuated total reflection (ATR) sampling, it is gradually used for quantification. Mid-infrared ATR quantification and secondary quantification based on multivariate statistics show that infrared spectroscopy has quantitative capabilities. [0003] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/3563
CPCG01N21/3563
Inventor 粟晖姚志湘潘浩然黄晓程张景清
Owner JK SUCRALOSE
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