Application of KGF to preparation of drugs used for treating or preventing radiation enteritis

A technology for radiation enteritis and its use, which is applied in the application field of KGF in the preparation of medicines for the treatment or prevention of radiation enteritis, and can solve problems such as serious illness, non-radiation enteritis treatment means, and difficult treatment

Inactive Publication Date: 2018-03-06
CHINA INST FOR RADIATION PROTECTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The incidence of radiation enteritis caused by radiation therapy is as high as 10% to 60%. Once radiation enteritis occurs, the treatment is difficult, and the condition is serious and persistent. At present, there is still no effective treatment for radiation enteritis in clinic.

Method used

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  • Application of KGF to preparation of drugs used for treating or preventing radiation enteritis
  • Application of KGF to preparation of drugs used for treating or preventing radiation enteritis
  • Application of KGF to preparation of drugs used for treating or preventing radiation enteritis

Examples

Experimental program
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Effect test

Embodiment 1

[0014] Embodiment 1: the mouse animal experiment of KGF treatment radiation enteritis

[0015] 1. Main reagents and experimental animals

[0016] SPF grade Kunming mice, male and female, 6-8 weeks old, weighing 26-28g, were raised and managed in the Animal Laboratory of GLP Center, China Institute of Radiation Protection. KGF was purchased from Chongqing Fujin Biomedical Co., Ltd.

[0017] 2. Radiation exposure conditions

[0018] The cobalt-60 teletherapy machine of the Affiliated Hospital of China Institute of Radiation Protection was used. The manufacturer: Equipment Manufacturing Plant of China Nuclear Power Research and Design Institute; model: GWGP80. The gamma rays of cobalt-60 teletherapy machine were used to irradiate, the source-skin distance was 80cm, the irradiation field was the whole abdomen (sternoxiphoid process to pubic symphysis), the radiation dose rate was 0.678Gy / min, and the total dose was 8Gy or 10Gy.

[0019] 3. Experimental grouping

[0020] After ...

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PUM

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Abstract

The invention relates to application of KGF to preparation of drugs used for treating or preventing radiation enteritis, belonging to the field of biological medicine. As KGF is applied to treatment or prevention of radiation enteritis, the symptoms of radiation enteritis can be eliminated or prevented, and intestinal injury caused by radioactive irradiation can be avoided, repaired and/or improved.

Description

technical field [0001] The present invention generally relates to the use of KGF in the preparation of medicines for treating or preventing diseases. Background technique [0002] Radiation enteritis is a common intestinal complication caused by radiation therapy for pelvic and abdominal malignancies, and radiation therapy is a common method for the treatment of pelvic and abdominal malignancies. The incidence of radiation enteritis caused by radiation therapy is as high as 10% to 60%. Once radiation enteritis occurs, the treatment is difficult, and the condition is serious and persistent. At present, there is still no effective treatment for radiation enteritis. Therefore, research on the prevention and treatment of radiation enteritis has important clinical and theoretical value. [0003] KGF (Keratinocyte Growth Factor, keratinocyte growth factor) is one of the members of the fibroblast growth factor family. It is a single-chain polypeptide isolated from embryonic fibrob...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61P1/00
CPCA61K38/1825
Inventor 王超任越刘红艳张忠新董娟聪蔺素琴周晋源原雅艺张睿凤段志凯左雅慧
Owner CHINA INST FOR RADIATION PROTECTION
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