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Whitening composition and its preparation method and use

A composition and whitening technology, which can be applied in pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve problems such as skin whitening that cannot be comprehensively considered, and achieve a highly synergistic effect

Active Publication Date: 2020-09-11
GUANGZHOU KENENG COSMETICS RES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned skin whitening agents cannot comprehensively consider all aspects of skin whitening, such as: from the inducement of melanin production, the process of melanin production to the final process of melanin digestion and discharge, etc.

Method used

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  • Whitening composition and its preparation method and use
  • Whitening composition and its preparation method and use
  • Whitening composition and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0047]Scutellaria baicalensis (SCUTELLARIA BAICALENSIS) extract can be obtained by purchasing, or can be prepared by extracting by cold water extraction. Specifically, the preparation method of the Scutellaria baicalensis extract comprises: extracting the weighed Scutellaria baicalensis with cold water twice, the first time is 10-15 times the amount, 1-3 hours, and the second time is 8-12 times the amount, 0.5-2.5 hours. Filter and concentrate the filtrate, then add HCl to adjust the pH to 1-2, keep the temperature in a water bath at 60-100°C for 20-40min, remove the supernatant, add distilled water and stir evenly. Then add 20-60% sodium hydroxide to adjust the pH to 6-8, then add 200-300 mL of 70-90% ethanol, and dissolve in a water bath at 70-90° C. for 5-20 minutes. After filtration, take the filtrate and add HCl to adjust the pH to 1-2, place it in a water bath at 50-70°C for 20-40 minutes, remove the supernatant after standing still, wash twice with distilled water, then...

Embodiment 1-6

[0087] According to the content of each component in Table 1 below, the whitening essences of Examples 1-6 were prepared based on a total weight of 100 g.

[0088] Table 1

[0089]

[0090] The preparation method of the whitening essence in the above-mentioned embodiment 1-6 comprises the following steps:

[0091] 1) Mix and stir the oxidized resveratrol and propylene glycol until completely dissolved, and set aside;

[0092] 2) After mixing the licorice glabra extract and dipropylene glycol, heat it to 60°C until it dissolves completely, and cool it to room temperature for later use;

[0093] 3) Heat deionized water, EDTA-2Na, propylene glycol, glycerin, dipropylene glycol, and hydroxyethyl cellulose to 80°C, stir and dissolve until completely dissolved, and keep stirring for 20 minutes;

[0094] 4) Stir and cool down to 40°C, add the mixture of oxidized resveratrol and propylene glycol in the whitening composition (ie: step 1), extract of scutellaria baicalensis, extrac...

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Abstract

The invention relates to a whitening composition and a preparation method as well as application thereof. The whitening composition is prepared from the following components in percentage by mass: 0.01 to 10 percent of oxyresveratrol, 0.01 to 20 percent of radix scutellariae extract, 0.01 to 10 percent of herba thymi mongolici extract, 0.01 to 10 percent of fructus chebulae extract, 0.01 to 15 percent of hydrolyzed prunus domestica, 0.5 to 20 percent of nicotinamide and 0.01 to 10 percent of radix glycyrrhizae glabrae extract. According to the whitening composition disclosed by the invention,a balanced whitening effect can be achieved, i.e., all links of skin whitening can be comprehensively considered, and specifically, all links of melanogenesis incentives (inflammation), a melanogenesis process, a process of blocking transfer of melanin, a process of inhibiting phagocytosis of keratinocyte on the melanin, preventing the melanin from entering the stratum corneum, inhibiting color development and finally digesting and discharging the melanin and the like can be comprehensively considered.

Description

technical field [0001] The invention relates to a whitening composition, a preparation method and application thereof, and belongs to the field of cosmetics. Background technique [0002] "Whitening skin" is the eternal topic and pursuit of beauty lovers. The research and development, safety and efficacy evaluation of whitening skin care products have naturally become the focus of attention of researchers, producers, operators and consumers. The color of the skin is mainly determined by the content and distribution of skin pigments, and melanin is the most important determinant. Melanocytes in the skin produce melanin, and the melanin granules transfer to the keratinocytes through the melanocyte dendrites, and the melanin granules transferred to the keratinocytes go up to the stratum corneum along with the epidermal cells, thereby affecting the color of the skin or forming spots, and finally with the stratum corneum shed and excreted. [0003] In addition, the irradiation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/67A61K8/34A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/347A61K8/675A61K8/97A61K2800/5922A61K2800/782A61Q19/00A61Q19/02A61Q19/08
Inventor 崔英云王秋静刘孟刘德海张伟杰张楚标
Owner GUANGZHOU KENENG COSMETICS RES CO LTD
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