30results about How to "Inhibition of phagocytosis" patented technology

The invention discloses a traditional Chinese medicinal composition for treating infant eczema, acute and chronic eczema, and eczematous dermatitis. The traditional Chinese medicinal composition consists of 20-200 parts of egg oil, 0.5-50 parts of borneol and 0.4-5 parts of shrubby sophora extract. The composition, through a process, can be prepared into clinically acceptable dosage forms, such as an oil agent, an ointment, a gel, a soft capsule, a nano preparation and the like, which are concrete in therapeutic effect and convenient to use, carry and store. Both pharmacological study and clinical research show that the composition has functions of clearing away heat and toxic matters, removing dampness and relieving itch, and the composition is used for treating infant eczema, acute and chronic eczema, and eczematous dermatitis caused by interactive damp and hot; and the composition is free from side effect and capable of promoting aged skin renewal, and has a wide market prospect and social and economic values.

The invention relates to the field of application of spiroketal compounds, in particular to application of a compound, namely 5'-epi-SPA-6952A, to preparation of insect immunosuppressor. The compound, namely 5'-epi-SPA-6952A, restrains the functions of an insect immune system, and the structural formula of the compound, namely 5'-epi-SPA-6952A, is shown in the description. The compound has a novel action mechanism, the restraining effect of the compound on the injurious insect immune system is different from that of action mechanisms of existing insecticides, and the compound is not influenced by the drug resistance of insects to other insecticides, has the advantage of being friendly to the environment, and has good application prospects on insect control and injurious insect physiological adaptation regulation and control.

The present invention relates to a method for producing microalloy ferro-silicon by using a nickle smelting waste slag electric stove integral deoxidation and reduction, including the steps as follows: a. obtaining a ferro-silicon of a high-temperature molten state by deoxidation and reduction of the nickle smelting waste slag as an iron raw material and other raw material; b. pouring the ferro-silicon into a foundry ladle to insulate to ensure the ferro-silicon to be in the molten state, at the same time infusing chlorine gas into the ferro-silicon to generate solid residue to purify; c. removing the solid residue. For the method of the invention, the nickel smelting waste slag is directly used to replace the iron raw material such as steel shaving, iron scale, sintered ball cluster and the like for the ferro-silicon production, thus it is capable of reducing the dosage of dinas rock or rock quartz; it has been found that the ferro-silicon (FeSi75) produced by the method meets the national standard completely; the invention provides a novel method for producing ferroalloy.

The invention relates to a medicine for treating scabies. The medicine is prepared from the following components in parts by weight: 1-3 parts of raw rhubarb, 1-2 parts of camphor, 3-4 parts of sulphur, 1-2 parts of cortex pseudolaricis, 1 part of calamine and 1 part of zinc oxide. A topical ointment is prepared by mixing the components evenly and crushing the components into medicine powder of 80-100 meshes; and adding 25g of glycerin and 25g of Vaseline to each 50g of medicine powder, stirring evenly and carrying out sterilization and disinfection. The medicine is simple and reasonable in formula; various components are mutually matched and supplemented by one another; the medicine has an obvious curative effect on scabies, is free of recurrence after healing, is capable of killing sarcoptic mites, relieving itching, expelling toxin, astringing dampness and healing sores, is free of toxic or side effect and low in cost, and can be widely applied to various areas, especially rural areas short of medical services and medicines; and the burden of the people is relieved while the scabies is effectively treated.

The invention discloses a baby eczema lotion and a preparation method thereof. The lotion comprises the components of, by weight: 50-100 parts of redroot gromwell, 45-90 parts of light-yellow sophora root, 30-100 parts of Taiwan angelica root, and 60-120 parts of fragrant solomonseal rhizome. According to the invention, on a basis of heat clearing and dampness eliminating of traditional baby eczema treatment, a blood-cooling and detoxifying method is adopted. Also, considering the characteristics of baby skins, blood-cooling detoxifying, wind-evil-dispelling, dampness-eliminating, heat-clearing, itching-relieving, and skin-moisturizing traditional Chinese medicines are adopted for preparing the lotion, such that baby skins can be moisturized when baby eczema is cured. No significant side effect is found currently. The invention also discloses a preparation method of the baby eczema lotion.

The present invention relates to a polypeptide, a lipid carrier modified by the polypeptide and its application as a drug for inhibiting the phagocytosis of macrophages. The present invention provides a nano-preparation that can be absorbed for a long time on the basis that it is easily phagocytized by macrophages during delivery in vivo A method to facilitate intrananoparticle delivery on the surface of macrophage cell membranes. After the "Self" D-type polypeptide and phospholipids or other materials are used to form a lipid carrier, when it interacts with macrophages, it can reside on the surface of macrophages for a long time, inhibiting the phagocytosis of macrophages, thereby significantly improving nanocarriers. in vivo delivery. The lipid carrier of the invention can be adsorbed on the surface of macrophages and promote the phosphorylation of SIRPα protein in macrophages to inhibit the phagocytosis of macrophages. After entering the body, it can inhibit the phagocytosis of macrophages and prolong the in vivo half-life of the subsequently injected drug. The research of the present invention shows that by administering the lipid carrier, the half-life of the nano-preparation in the body can be significantly prolonged, and the distribution of the drug in the liver and spleen can be reduced.

The invention relates to a whitening composition and a preparation method as well as application thereof. The whitening composition is prepared from the following components in percentage by mass: 0.01 to 10 percent of oxyresveratrol, 0.01 to 20 percent of radix scutellariae extract, 0.01 to 10 percent of herba thymi mongolici extract, 0.01 to 10 percent of fructus chebulae extract, 0.01 to 15 percent of hydrolyzed prunus domestica, 0.5 to 20 percent of nicotinamide and 0.01 to 10 percent of radix glycyrrhizae glabrae extract. According to the whitening composition disclosed by the invention,a balanced whitening effect can be achieved, i.e., all links of skin whitening can be comprehensively considered, and specifically, all links of melanogenesis incentives (inflammation), a melanogenesis process, a process of blocking transfer of melanin, a process of inhibiting phagocytosis of keratinocyte on the melanin, preventing the melanin from entering the stratum corneum, inhibiting color development and finally digesting and discharging the melanin and the like can be comprehensively considered.

The invention relates to a method for manufacturing a digital PCR (polymerase chain reaction) chip based on a mineral-oil saturated PDMS (polydimethylsiloxane) material. The method is characterized in that the digital PCR chip based on PDMS is prepared from a PDMS monomer of a certain amount of mineral oil (liquid paraffin) and comprises an emulsion droplet generation structure and an emulsion droplet collection structure. After the emulsion droplets are made and collected on the same chip, the emulsion droplets are subjected to PCR amplification on the same chip. The phagocytosis to the oil phase in the digital PCR system by the PDMS of the chip can be avoided, the emulsion droplets can be kept stable during PCR, and the stability of the PCR can be guaranteed. In addition, compared with the existing technology of the digital PCR chip, the method provided by the invention is low in cost, is convenient to operate and has a very wide application prospect.