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Composition for inhibiting PAR-2 from activating keratinocytes and application of composition to facial mask

A technology of PAR-2 ​​and keratinocytes, applied in the direction of cosmetics, cosmetic preparations, dressing preparations, etc., can solve the problems of skin barrier damage, tingling, redness, etc., to prevent accumulation and deposition, and prevent pigmentation Effect

Active Publication Date: 2021-11-09
SHANGHAI YAOJIAN BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its effective time is relatively fast, but it also bears some risks. Dry skin, peeling, itching, tingling, redness, burning sensation and other discomfort symptoms may occur, and the skin barrier is also easily damaged.

Method used

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  • Composition for inhibiting PAR-2 from activating keratinocytes and application of composition to facial mask
  • Composition for inhibiting PAR-2 from activating keratinocytes and application of composition to facial mask
  • Composition for inhibiting PAR-2 from activating keratinocytes and application of composition to facial mask

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The present embodiment provides a facial mask, which is prepared by immersing a membrane cloth into an essence containing a composition inhibiting PAR-2 ​​activation of keratinocytes (PAR-2 ​​inhibitor), and the essence includes the following table 1 by weight percentage Ingredients in:

[0053] The essence composition and proportioning of table 1 embodiment 1

[0054]

[0055]

[0056] The method for preparing above-mentioned facial mask, comprises the following steps:

[0057] S1: Weigh the quality of raw materials according to the ratio of raw materials, and disperse all moisturizing agents with glycerin for later use;

[0058] S2: Dissolve p-hydroxyacetophenone in polyol at 80-85°C, dissolve evenly, and form a p-hydroxyacetophenone solution for later use;

[0059] S2: Add acrylic acid (ester) / C10-30 alkanol acrylate cross-linked polymer to the main pot and soak in deionized water for 10 minutes until the material is wet, and add all the moisturizers prepared...

Embodiment 2

[0063] The present embodiment provides a facial mask, which is prepared by immersing membrane cloth into an essence containing a composition inhibiting PAR-2 ​​activation of keratinocytes (PAR-2 ​​inhibitor), and the essence includes the following table 2 by weight percentage Ingredients in:

[0064] The essence composition and proportioning of table 2 embodiment 2

[0065]

[0066]

[0067] Embodiment 2 The method for preparing facial mask is the same as embodiment 1.

Embodiment 3

[0069] The present embodiment provides a facial mask, which is prepared by immersing a membrane cloth in an essence containing a composition inhibiting PAR-2 ​​activation of keratinocytes (PAR-2 ​​inhibitor), and the essence includes the following table 3 by weight percentage Ingredients in:

[0070] The essence composition and proportioning of table 3 embodiment 3

[0071]

[0072]

[0073] The method for preparing facial mask of embodiment 3 is the same as embodiment 1.

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Abstract

The invention relates to a composition for inhibiting PAR-2 from activating keratinocytes and an application of the composition to facial masks, and provides a composition for inhibiting PAR-2 from activating keratinocytes. The composition comprises trehalose, bio-saccharide gum-1, nicotinamide and tranexamic acid. PAR-2 is used as an action target, by inhibiting the activity of PAR-2, the mediation effect of PAR-2 on melanin transport is influenced, the phagocytosis of keratinocytes activated by PAR-2 on melanin bodies is inhibited, accumulation and deposition of melanin in cuticle are hindered, and the pigmentation problem in the state of ultraviolet irradiation or skin inflammation is prevented. The composition is also applied to a facial mask, and the facial mask for inhibiting hyperpigmentation is provided. A test experiment shows that the facial mask disclosed by the invention has an inhibiting effect on PAR-2 activity, melanogenesis and chromatosis, and is relatively good in product safety.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a composition for inhibiting PAR-2 ​​and activating keratinocytes and its application in facial masks. Background technique [0002] Hyperpigmentation is the darkening of skin color due to increased pigmentation due to various reasons. The most common cause is sun exposure, but it can also be caused by genetic, metabolic, endocrine, tumor, inflammatory diseases, physical, mechanical, chemical stimuli, and congenital factors. The main clinical manifestations are darkening of the skin or the appearance of spots, patches or plaques that are darker than normal skin color. At present, skin pigmentation is mainly aimed at improving after occurrence, and more treatment strategies are to lighten or peel off the deposited pigment, including using vitamin C to restore melanin to melanin precursor and rejuvenating the stratum corneum, etc. The former The treatment cycle is l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/44A61K8/60A61K8/67A61K8/73A61Q17/04A61Q19/00
CPCA61K8/60A61K8/73A61K8/675A61K8/44A61K8/0212A61Q19/00A61Q17/04A61Q19/004A61K2800/782A61K2800/592
Inventor 刘传伟
Owner SHANGHAI YAOJIAN BIO TECH
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