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Hyaluronic acid-based postoperative anti-adhesive membrane

A technology of hyaluronic acid and base surgery, applied in surgery, medical science, etc., can solve the problems of poor anti-adhesion effect, achieve the effects of reducing friction, inhibiting inflammatory cell migration and phagocytosis, and inhibiting fibrin deposition

Inactive Publication Date: 2014-09-03
ZHANGJIAGANG SHANMU NEW MATERIAL TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: in order to overcome the poor postoperative anti-adhesion effect of the postoperative anti-adhesion film in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A hyaluronic acid-based postoperative anti-adhesion film, the components and the weight percentage of each component are: 55% hyaluronic acid with a molecular weight of 8700, 8% glycerin, 5% citric acid, and 1% gentamicin , and the balance is water.

[0020] A method for preparing a hyaluronic acid-based postoperative anti-adhesion film, comprising the steps of:

[0021] Step 1) Take each component according to the weight percentage content, fully stir evenly, then prepare a solution with a mass concentration of 4wt%, fully stir to form a uniform solution,

[0022] Step 2) The homogeneous solution obtained in step 1) is poured into a spin coater and spin-coated evenly, dried at 60°C to form a film, and the film is peeled off after cooling to obtain a hyaluronic acid-based postoperative anti-adhesion film.

Embodiment 2

[0024] A hyaluronic acid-based postoperative anti-adhesion film, the components and the weight percentage of each component are: 96% hyaluronic acid with a molecular weight of 8700, 1% glycerin, 0.5% ciprofloxacin, and the balance is water .

[0025] A method for preparing a hyaluronic acid-based postoperative anti-adhesion film, comprising the steps of:

[0026] Step 1) Take each component according to the weight percentage content, fully stir evenly, then prepare a solution with a mass concentration of 10wt%, and fully stir to form a homogeneous solution,

[0027] Step 2) The homogeneous solution obtained in step 1) is poured into a spin coater and spin-coated evenly, dried at 60°C to form a film, and the film is peeled off after cooling to obtain a hyaluronic acid-based postoperative anti-adhesion film.

Embodiment 3

[0029] A hyaluronic acid-based postoperative anti-adhesion film, the components and the weight percentage of each component are: 80% hyaluronic acid with a molecular weight of 8700, 5% glycerin, 1% citric acid, 0.7% metronidazole, The balance is water.

[0030] A method for preparing a hyaluronic acid-based postoperative anti-adhesion film, comprising the steps of:

[0031] Step 1) Take each component according to the weight percentage content, fully stir evenly, then prepare a solution with a mass concentration of 8wt%, fully stir to form a uniform solution,

[0032] Step 2) The homogeneous solution obtained in step 1) is poured into a spin coater and spin-coated evenly, dried at 60°C to form a film, and the film is peeled off after cooling to obtain a hyaluronic acid-based postoperative anti-adhesion film.

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Abstract

The invention relates to the technical field of biological materials and particularly relates to a hyaluronic acid-based postoperative anti-adhesive membrane. The hyaluronic acid-based postoperative anti-adhesive membrane consists of the following components in percentage by weight: 55%-96% of hyaluronic acid, 1%-8% of glycerol, 0%-5% of citric acid, 0.5%-1% of antibiotics and the balance of water. The hyaluronic acid-based postoperative anti-adhesive membrane disclosed by the invention is used for separating an injured tissue from a normal serosa to achieve space-blocking and lubricating effects, and therefore, friction is reduced; bleeding and effusion are inhibited, number of blood blocks forming a permanent adhesion skeleton can be reduced, and fibrous protein deposition is inhibited; postoperative inflammatory cell transfer and phagocytosis are inhibited, and wound healing is promoted; growth and differentiation of serosa mesothelial cells are stimulated, so that the inured serosa achieves physiological repair, and therefore, the hyaluronic acid-based postoperative anti-adhesive membrane has excellent postoperative anti-adhesive effect.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a hyaluronic acid-based postoperative anti-adhesion film. Background technique [0002] As a common clinical phenomenon, postoperative adhesions can lead to serious clinical complications, such as intestinal obstruction, abdominal and pelvic pain, infertility, etc., increasing the difficulty of reoperation and the potential risk of further complications. Adhesions are often associated with tissue repair after general abdominal, gynecological, orthopedic, and cardiovascular procedures, often occurring when separated tissue surfaces stick together, and can be explained as attachments between tissues and organs. When adhesions interfere with normal tissue function, they become postoperative complications. Foreign surveys have found that 54% to 74% of small bowel obstruction is caused by abdominal adhesions. The main causes of pelvic adhesions in women are surgery, infection a...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/16
Inventor 顾钰霞
Owner ZHANGJIAGANG SHANMU NEW MATERIAL TECH DEV
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