The invention discloses a pressing hemostasis device for cardiovascular surgery in the internal medicine department, and relates to the technical field of medical treatment. The device comprises a base, pressure hemostatic gauze, a supporting frame and an expanding mechanism, an unwinding box and a first clamping mechanism are arranged on the left side face of the base, a second clamping mechanism and a cutting mechanism are arranged on the right side face of the base, a winding drum is rotationally arranged in the unwinding box, a pressure hemostatic gauze is wound on the winding drum, and the pressure hemostatic gauze sequentially penetrates through the first clamping mechanism, the second clamping mechanism and the cutting mechanism. When the pressure hemostatic gauze is pressed, the pressure hemostatic gauze is completely expanded through the expanding mechanism, the pressure hemostatic gauze is prevented from deviating or gathering together, the hemostatic effect is greatly improved, and the pressure hemostatic gauze is convenient to replace by arranging the unwinding box, the winding drum and the cutting mechanism; and the problems that according to an existing hemostasis device, pressure hemostasis gauze is not convenient to replace, deviation is prone to occurring during pressing, and the hemostasis effect is not ideal are solved.