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Copper and Schiff base complex and preparation method and application thereof

A technology of complexes and Schiff bases, applied in copper organic compounds, organic chemical methods, 1/11 group organic compounds without C-metal bonds, etc., can solve problems such as cumbersome operations, low yields, and long reaction times , to achieve the effect of simple preparation process, short cycle and avoiding pollution

Active Publication Date: 2018-03-23
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the technical problems of cumbersome operation, long reaction time, low yield and potential safety hazards in the existing method for preparing copper Schiff base complexes, and to provide a copper Schiff base complex that can be used as a bacteriostatic agent. Alkali complex and its preparation method and application

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  • Copper and Schiff base complex and preparation method and application thereof
  • Copper and Schiff base complex and preparation method and application thereof
  • Copper and Schiff base complex and preparation method and application thereof

Examples

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Embodiment 1

[0019] A copper Schiff base complex in the present embodiment, the molecular formula of the complex is [Cu 2 (HL) 2 (OAc) 2 ] n , wherein HL is hydrazino-(2-pyridyl) salicylaldimine, n represents the number of repeating units, and the structural formula of the complex is:

[0020]

[0021] The crystal of the complex belongs to the monoclinic system, the space group is C2 / c, and the unit cell parameters are: α=90 o , β=120.7(6) o , γ=90 o . The structural units of the complex are composed of 2 copper ions, 2 hydrazino-(2-pyridyl) salicylaldimines and 2 acetate groups. The central Cu(II) coordinates with three atoms in the ligand HL and two O atoms in two different carboxylic acids respectively, forming a pentacoordinated tetrahedron structure. The bond lengths between Cu(II) and the coordination atoms are:

[0022] The preparation method of above-mentioned copper Schiff base complex, comprises the steps:

[0023] Weigh 0.1mmol Cu(OAc) 2 ·H 2 O, 0.2...

Embodiment 2

[0025] A kind of copper Schiff base complex in the present embodiment is identical with embodiment 1, and its preparation process is as follows:

[0026] Weigh 0.1mmol Cu(OAc) 2 ·H 2 O, 0.2mmol of 2-hydrazinopyridine and 0.2mmol of salicylaldehyde were added to a polytetrafluoroethylene tube containing 4mL of methanol, and the polytetrafluoroethylene tube was sealed in a stainless steel reactor, heated at 90°C for 60h, and then cooled down naturally , black rod-shaped crystals were precipitated, washed with methanol solution and dried to obtain the copper Schiff base complex.

Embodiment 3

[0028] A kind of copper Schiff base complex in the present embodiment is identical with embodiment 1, and its preparation process is as follows:

[0029] Weigh 0.1mmol Cu(OAc) 2 ·H 2 O, 0.2mmol of 2-hydrazinopyridine and 0.2mmol of salicylaldehyde were added to a polytetrafluoroethylene tube containing 5mL of methanol, and the polytetrafluoroethylene tube was sealed in a stainless steel reactor, heated at 100°C for 48h, and then cooled down naturally , black rod-shaped crystals were precipitated, washed with methanol solution and dried to obtain the copper Schiff base complex.

[0030] Elemental analysis was carried out on the product obtained in the above examples, the theoretical value: C, 54.51; H, 4.39; N, 15.26; experimental value: C, 54.58; H, 4.09; N, 15.29.

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Abstract

The invention relates to a copper and Schiff base complex and a preparation method and application thereof, and aims to solve the technical problems that a conventional copper and Schiff base complexpreparation method is troublesome in operation, long in reaction time and low in productivity and has potential safety hazards. The copper and Schiff base complex has the molecular formula [Cu2(HL)2(OAc)2]n, wherein HL is diazanyl-(2-pyridyl)salicylaldimine. The preparation method of the copper and Schiff base complex comprises the following steps: adding Cu(OAc)2.H2O, 2-hydrazinylpyridine and salicylaldehyde of which the molar ratio is 1:2:2 into a polytetrafluoroethylene tube containing methyl alcohol, wherein the molar volume ratio of Cu(OAc)2.H2O to methyl alcohol is 0.1:(3-5) mmol / ml; performing a reaction for 48-72 h at 80-100 DEG C; performing natural cooling to separate out black rhabdolith; and after washing with a methanol solution, performing drying to prepare the copper and Schiff base complex. The copper and Schiff base complex has a powerful bacterial inhibition function on escherichia coli, staphylococcus aureus and bacillus subtilis, has a favorable potential application prospect in the field of biological activity, and can serve as a novel antibacterial agent.

Description

technical field [0001] The invention relates to a copper Schiff base complex and its preparation method and application. Background technique [0002] Transition metal complexes have broad application prospects in the fields of catalysis, luminescence, and biomedicine due to their optical, electrical, and magnetic properties. Modern medical research shows that copper complexes can produce antibacterial, antiviral, anti-inflammatory, antitumor, enzyme inhibition or chemical nuclease activities, and have received more and more attention. As a common organic compound, Schiff bases can coordinate with many metal ions to form stable complexes due to their simple preparation and diverse structures. Therefore, Schiff bases are ideal ligands for the synthesis of transition metal complexes. At the same time, most Schiff base compounds have biological activities such as antitumor and antibacterial, and play a role in transamination in biochemical reactions. The carbon-nitrogen double...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F1/08A61P31/04
CPCC07B2200/13C07F1/005Y02A50/30
Inventor 曹炜刘耀明张婷贾金萍
Owner SHANXI UNIV
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