A method for improving the gas-barrier property of pharmaceutical plastic containers

A technology for plastic containers and gas permeability, which is applied in the field of improving the gas barrier properties of pharmaceutical plastic containers, can solve the problems of high temperature resistance and gas barrier properties that cannot meet the requirements of use, and achieve high temperature resistance, avoid aging problems, and improve gas resistance. The effect of breathability

Active Publication Date: 2020-04-10
安徽益顺塑业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the prior art, there are many types of plastic packaging containers, among which, the plastic containers used for packaging medicines should meet the requirements of not polluting medicines, low cost, durable, with certain strength, toughness, and good aging resistance. The raw materials used for plastic packaging containers for medicines mainly include polyethylene plastics, polyvinyl chloride, etc., because polyethylene is odorless, non-toxic, feels like wax, has excellent low temperature resistance, good chemical stability, and can withstand general requirements Most of the acid-base corrosion, insoluble in common solvents at room temperature, low water absorption, excellent electrical insulation, therefore, has been widely used in the production of packaging containers; but the existing raw materials for the production of plastic containers are basically selected Polyethylene with a single molecular weight and a single molecular density was found to be unable to meet the requirements for high temperature resistance and gas barrier performance during the long-term storage of drugs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] A method for improving the gas barrier property of a pharmaceutical plastic container, comprising adding a mixing aid equivalent to 4% of its weight in polyethylene raw materials and mixing them thoroughly; the polyethylene raw materials include by weight: a molecular weight of 48 parts of polyethylene with a molecular weight of 100,000 to 300,000, 8 parts of polyethylene with a molecular weight of 50,000 to 100,000, 2 parts of polyethylene with a molecular weight of 300,000 to 500,000, and modified polyethylene with a molecular weight of 3 million to 6 million 6 copies;

[0014] The preparation method of the modified polyethylene with a molecular weight of 3 million to 6 million is as follows: the polyethylene material with a molecular weight of 3 million to 6 million is placed at a distance of 5 cm from the electrode, at a vacuum degree of 29.83 Pa and a discharge voltage of 600 V , The current density is 0.07mA / c㎡, and the processing time is 25 seconds;

[0015] The...

Embodiment 2

[0020] A method for improving the gas barrier property of a pharmaceutical plastic container, comprising adding a mixing aid equivalent to 2% by weight of the polyethylene raw material and mixing it thoroughly; the polyethylene raw material includes by weight: a molecular weight of 50 parts of polyethylene with a molecular weight of 100,000 to 300,000, 6 parts of polyethylene with a molecular weight of 50,000 to 100,000, 1 part of polyethylene with a molecular weight of 300,000 to 500,000, and modified polyethylene with a molecular weight of 3 million to 6 million 4 parts;

[0021] The preparation method of the modified polyethylene with a molecular weight of 3 million to 6 million is as follows: the polyethylene material with a molecular weight of 3 million to 6 million is placed at a distance of 6 cm from the electrode, at a vacuum degree of 28.52 Pa and a discharge voltage of 550 V , the current density is 0.06mA / c㎡, and the processing time is 28 seconds;

[0022] The mixi...

Embodiment 3

[0027] A method for improving the gas barrier property of a pharmaceutical plastic container, comprising adding a mixing aid equivalent to 6% of its weight in polyethylene raw materials and mixing them thoroughly; the polyethylene raw materials include in parts by weight: a molecular weight of 44 parts of polyethylene with a molecular weight of 100,000 to 300,000, 10 parts of polyethylene with a molecular weight of 50,000 to 100,000, 3 parts of polyethylene with a molecular weight of 300,000 to 500,000, and modified polyethylene with a molecular weight of 3 million to 6 million 8 copies;

[0028] The preparation method of the modified polyethylene with a molecular weight of 3 million to 6 million is as follows: the polyethylene material with a molecular weight of 3 million to 6 million is placed at a distance of 4 cm from the electrode, at a vacuum degree of 31.28 Pa and a discharge voltage of 650 V , The current density is 0.08mA / c㎡, and the processing time is 22 seconds;

...

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Abstract

The invention belongs to the technical field of medicinal plastic containers and particularly relates to a method for increasing the airtightness of a medicinal plastic container. The method includes:adding mixing auxiliaries with the weight being 2-6% of the weight of a polyethylene raw material into the polyethylene raw material, and sufficiently mixing, wherein the polyethylene raw material comprises polyethylene with the molecular weight being 0.1-0.3 million, polyethylene with the molecular weight being 0.05-0.1 million, polyethylene with the molecular weight being 0.3-0.5 million and polyethylene with the modified molecular weight being 3-6 million. Compared with the prior art, the method has the advantages that dielectric barrier discharge is utilized to modify the ultrahigh-molecular-weight polyethylene material, the modified material is mixed with other raw materials to prepare the plastic container, material compatibility can be enhanced, the high-temperature resistance andairtightness of the material can be increased effectively, and medicine pollution during long-term use of the container can be avoided; the method is simple in process, easy in condition control, capable of reducing the decomposition of additives and capable of expanding the application range of the polyethylene material.

Description

technical field [0001] The invention belongs to the technical field of medicinal plastic containers, and in particular relates to a method for improving the gas barrier properties of medicinal plastic containers. Background technique [0002] In the prior art, there are many types of plastic packaging containers, among which, the plastic containers used for packaging medicines should meet the requirements of not polluting medicines, low cost, durable, with certain strength, toughness, and good aging resistance. The raw materials used for plastic packaging containers for medicines mainly include polyethylene plastics, polyvinyl chloride, etc., because polyethylene is odorless, non-toxic, feels like wax, has excellent low temperature resistance, good chemical stability, and can withstand general requirements Most of the acid-base corrosion, insoluble in common solvents at room temperature, low water absorption, excellent electrical insulation, therefore, has been widely used i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L23/06C08L93/04C08L75/14C08L91/00C08K13/04C08K7/24C08K5/10C08K5/41C08J3/28
CPCC08J3/28C08J2323/06C08K2201/003C08K2201/011C08L23/06C08L2201/08C08L2201/14C08L2203/02C08L2205/025C08L2205/035C08L2207/068C08L93/04C08L75/14C08L91/00C08K13/04C08K7/24C08K5/10C08K5/41
Inventor 谢涛屈山峰
Owner 安徽益顺塑业有限公司
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