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Oral colon locating preparation for preventing and treating colon cancer metastasis, preparation method and application thereof

A colon locating preparation, a technology for colon cancer, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, and pill delivery, etc. and other problems, to achieve the effect of preventing and treating colon cancer metastasis, with less side effects and strong targeting.

Active Publication Date: 2020-03-27
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem that arises is: injections can cause serious adverse reactions to traditional Chinese medicine injections due to factors such as medicinal materials and excipients.
However, the conventional oral dosage form starts to release the drug in the stomach and small intestine, and it is difficult for the drug to reach the colon or the concentration in the colon cancer site is low, which will affect the clinical therapeutic effect of the effective components of Prunella vulgaris on the disease
Based on the above-mentioned research results, the present invention further improves the existing technology, aims to solve the problem of a single drug release mechanism, and provides an oral drug with strong targeting and good stability for preventing and treating colon cancer metastasis. Colon targeting preparations

Method used

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  • Oral colon locating preparation for preventing and treating colon cancer metastasis, preparation method and application thereof
  • Oral colon locating preparation for preventing and treating colon cancer metastasis, preparation method and application thereof
  • Oral colon locating preparation for preventing and treating colon cancer metastasis, preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0030] Drug-loaded pill core prescription: including raw materials and auxiliary materials, the content of the raw material drug in the drug-loaded pill core is 20% of the weight of the drug-loaded pill core; the raw material drug is the effective part of Prunella vulgaris that can prevent and treat colon cancer metastasis; the patent announcement number is CN101317883B A preparation method for the anti-colon cancer active component (PVB) of Prunella vulgaris isolated from Prunella vulgaris has been disclosed. In this embodiment, the preparation steps of the bulk drug will not be repeated one by one.

[0031] Prunella vulgaris anti-colon cancer active component (PVB) 20%,

[0032]The excipients include: diluent: 10% dextrin, 67% starch, disintegrant: 2% sodium carboxymethyl starch, lubricant: 1% talcum powder. However, this embodiment should not be limited thereto. Diluents include but are not limited to dextrin, starch, and can also be one or more compositions of lactose, pr...

Embodiment 2

[0042] Drug-loaded pill core prescription: including raw materials and auxiliary materials, the content of the raw material drug in the drug-loaded pill core is 15% of the weight of the drug-loaded pill core; the raw material drug is the effective part of Prunella vulgaris that can prevent and treat colon cancer metastasis; the patent announcement number is CN101317883B A preparation method for isolating and obtaining anti-colon cancer active components of Prunella vulgaris from Prunella vulgaris has been disclosed. In this embodiment, the preparation steps of the bulk drug will not be repeated one by one.

[0043] Prunella vulgaris anti-colon cancer active component (PVB) 15%,

[0044] Excipients: 15% starch, 64% microcrystalline cellulose, 5% crospovidone, 1% talc.

[0045] Time-lag inner layer prescription: HPMC 100M is the coating material, PEG 6000 accounts for 8% by weight of HPMC 100M, talcum powder accounts for 10% by weight of HPMC 100M, and the coating weight increa...

Embodiment 3

[0054] Drug-loaded pill core prescription: including raw material medicine and auxiliary materials, the content of the raw material medicine in the drug-loaded pill core is 25% of the weight of the drug-loaded pill core; the raw material medicine is the effective part of Prunella vulgaris that can prevent and treat colon cancer metastasis; the patent announcement number is CN101317883B A preparation method for isolating and obtaining anti-colon cancer active components of Prunella vulgaris from Prunella vulgaris has been disclosed. In this embodiment, the preparation steps of the bulk drug will not be repeated one by one.

[0055] Prunella vulgaris anti-colon cancer active component (PVB) 25%, blank starch ball core 75%.

[0056] Time-lag inner layer prescription: HPMC 15M is the coating material, PEG 6000 accounts for 8% by weight of HPMC 15M, talcum powder accounts for 10% by weight of HPMC 15M, and the coating weight increases by 5%.

[0057] pH-dependent outer layer presc...

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Abstract

The invention relates to the field of pharmaceutical preparations, and discloses an oral colon-targeted preparation for preventing and treating colon cancer metastasis as well as a preparation methodand an application of the oral colon-targeted preparation. The preparation consists of a drug-loading pellet core, wherein a time-lag inner layer and a pH-dependent outer layer sequentially cover theexterior of the drug-loading pellet core, and the drug-loading pellet core contains a spica prunellae effective part which is capable of preventing and treating the colon cancer metastasis. The preparation method of the oral colon-targeted preparation disclosed by the invention comprises three steps, namely preparing the drug-loading pellet core, preparing the time-lag inner layer and preparing the pH-dependent outer layer. According to the embodiment provided by the invention, in comparison with the prior art, by sequentially covering the time-lag inner layer and the pH-dependent outer layeron the drug-loading pellet core, the colon-target preparation is strong in targeting performance and good in stability, so that the purpose of preventing and treating the colon cancer metastasis is achieved. In addition, the preparation is convenient to take and low in side effects.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an oral colon-localized preparation for preventing and treating colon cancer metastasis, a preparation method and application thereof. Background technique [0002] In recent years, with the improvement of people's living standards and changes in dietary structure, the incidence of colon cancer has been increasing year by year. The high morbidity and high mortality of colon cancer have seriously endangered human health and have gradually attracted widespread attention at home and abroad. It has been listed as one of the modern intractable diseases by the World Health Organization. At present, the incidence rate of colon cancer in my country is increasing at an annual rate of 4.2%, ranking third. Studies have found that the main cause of death from colon cancer is its invasion and metastasis. [0003] With the rapid development of science and technology, the means of d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K47/38A61K47/32A61K36/536A61P35/04
CPCA61K9/284A61K9/2866A61K9/2886A61K36/536
Inventor 刘力徐德生张建伟
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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