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Method for detecting trace illegal additives in medicines on basis of Raman spectra

A technology of illegal addition and Raman spectroscopy, applied in the field of detection, can solve the problems of difficult identification, inaccurate detection results, complicated operation, etc., to achieve the effect of rapid non-destructive detection, improve detection ability, and improve accuracy

Inactive Publication Date: 2018-04-13
天津富伟科技有限公司
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Problems solved by technology

[0003] The purpose of the present invention is to solve the problems of complex operation, small amount of collected information, difficult identification and inaccurate detection results of the existing detection methods in the background technology, and provide a detection method based on Raman spectroscopy for trace illegal additives in drugs method

Method used

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Embodiment Construction

[0020] This example is a method for detecting illegal additives in trace medicines based on Raman spectroscopy, which includes the following steps in turn:

[0021] S1: The laser emits laser light on the object to be detected and generates a Raman spectrum. In the actual detection process, a laser with a suitable wavelength can be determined according to the needs to emit laser light. In this example, the laser with a center wavelength of 780nm is used. The power of the laser is The power is 20 milliwatts, the integration time is 2000 milliseconds, and the average number of times is 10 times, ensuring high detection sensitivity and strong recognition of trace drug illegal additives, and ensuring accurate and reliable detection results;

[0022] S2: focusing the Raman spectrum of the laser into a light spot through a lens; the Raman spectrum is used to focus the Raman spectrum into a light spot through a lens to achieve high-magnification focusing;

[0023] S3: The light spots ...

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Abstract

The invention provides a method for detecting trace illegal additives in medicines on the basis of Raman spectra. The method sequentially includes steps of S1, emitting laser light on detected substances by the aid of laser devices and generating the Raman spectra; S2, focusing the Raman spectra via lenses to obtain light spots; S3, collecting the light spots by the aid of optical fibers and arraying the light spots to obtain narrow strip light; S4, sequentially carrying out diffraction and collimation processing on the narrow strip light and then carrying out chromatic dispersion reflection on the narrow strip light via reflecting gratings; S5, inputting Raman spectral signal light processed at the step S4 into photoelectric detectors via reflecting mirrors; S6, substituting spectral dataobtained at the step S5 into spectral libraries, detecting the trace illegal additives in the medicines and qualitatively and quantitatively analyzing the trace illegal additives. The method has theadvantages that micro-scale and trace illegal additives can be qualitatively and quantitatively analyzed by the aid of the method, stable and reliable analysis results can be obtained, and accordinglythe method has important significance in the medicine research field and the medical health field.

Description

technical field [0001] The invention belongs to the technical field of detection, and in particular relates to a method for detecting illegal trace drug additives based on Raman spectroscopy. Background technique [0002] In the existing technology, the detection of illegal trace drug additives is generally divided into three basic steps, namely: sampling, sample pretreatment and determination. It is an environmental sample, which often fluctuates greatly with time and space. The existing detection methods for illegal trace drug additives cannot meet the needs of detection. There is a need to pretreat the sample, which must be in contact with the sample, and the required sample volume is relatively large. Large and other problems, and there are technical problems such as the small amount of collected information and the difficulty of identification, resulting in inaccurate detection results. Contents of the invention [0003] The purpose of the present invention is to sol...

Claims

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Application Information

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IPC IPC(8): G01N21/65
Inventor 王斌徐晓轩
Owner 天津富伟科技有限公司
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