Shaking reactor

A reactor and reaction bag technology, applied in the field of shaking reactors, can solve the problems of easy foaming, shear force cell damage, complex fluid mechanics, etc.

Pending Publication Date: 2018-05-08
FOSHAN CANTON BIOLOGICS CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First of all, during the scale-up culture process, the shear force caused by the stirring paddles will cause damage to the cells, even death
Secondly, the stirred reactor generally adopts deep ventilation method, which is easy to generate foam, and at the s

Method used

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  • Shaking reactor

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Embodiment Construction

[0020] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the associated drawings. Preferred embodiments of the invention are shown in the accompanying drawings. However, the present invention can be embodied in many different forms and is not limited to the embodiments described herein. On the contrary, these embodiments are provided to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0021] It should be noted that when an element is referred to as being “fixed” to another element, it can be directly on the other element or there can also be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or intervening elements may also be present.

[0022] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as...

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PUM

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Abstract

The invention discloses a shaking reactor, which comprises a tank body, a shaking device, a reaction bag and a control device, wherein the tank body is connected onto the shaking device; the shaking device can drive the tank body to do annular rail type movement; the reaction bag is provided with a reaction cavity; the reaction bag is arranged in the tank body and is provided with a feeding opening, an inoculation opening, a material supplementing opening, an air inlet opening and an air outlet opening which communicate with the reaction cavity; the air inlet opening is positioned in the top of the reaction bag; the control device is electrically connected with the shaking device. The shaking reactor has the advantages that the shearing force damage can be avoided during the cell culture;the amplification culture process is simple.

Description

technical field [0001] The invention relates to a shaking reactor. Background technique [0002] At present, the world's biotechnology and pharmaceutical industry is developing rapidly. The expression and production of various diagnostic and therapeutic monoclonal antibodies, vaccines, growth factors and other biologically active proteins through in vitro culture of animal cells have a very broad market application prospect. Therefore, cell bioreactors used for large-scale high-density cultivation of animal cells have become the most important equipment in the biotechnology pharmaceutical industry. It largely determines the product cost, production scale and product category of biotechnology pharmaceutical companies. As cell culture has gradually become more complex, culture containers and culture methods have also become diverse for different cells and purposes. Suspension cell culture continues to improve, and the requirements for reactors are gradually increasing, inclu...

Claims

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Application Information

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IPC IPC(8): C12M3/00C12M1/02C12M1/04C12M1/00C12M1/36
CPCC12M27/02C12M27/16C12M29/00C12M41/00
Inventor 朱立宽冯建勋景涛韦庆焜沈潇
Owner FOSHAN CANTON BIOLOGICS CO LTD
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