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Application of 20s proteasome inhibitor in preparation of medicine for treating Japanese encephalitis virus infection
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A proteasome inhibitor, Japanese encephalitis virus technology, applied in the field of medicine
Active Publication Date: 2021-05-11
武汉百药联科科技有限公司
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At present, there is no precedent for the use of bortezomib, carfilzomib, and exazomib in the treatment of Japanese encephalitis virus infection
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Embodiment 1
[0036] Example 1 Application of bortezomib in the treatment of mice infected with Japanese encephalitis virus
[0037] 1. Establishment of a mouse model infected with Japanese encephalitis virus
[0038] 1. Experimental materials
[0039] (1) Experimental animals: four-week-old Balb / c female mice.
[0042] 1) 0.01M PBS buffer: weigh NaH 2 PO 4 0.593g, Na 2 HPO 4 5.802g, NaCl 17.0g, deionized water (ddH 2 O) Dilute to 2L, store at room temperature for later use.
[0043] 2) DMEM basal medium: a bottle of DMEM powder, weighed NaHCO 3 3.7g, HEPES 5.95g, add 800mLddH 2 O, stir well to dissolve, dilute to 1000mL, sterilize with a 0.22μm filter, and store at 4°C for later use.
[0044] 2. Experimental steps
[0045] Mice were injected intraperitoneally with 10 6 PFU Japanese encephalitis virus, the mice in the control group were intraperitoneally injected with the same dose of DMEM medium. At the su...
[0066] 1. Establishment of a mouse model infected with Japanese encephalitis virus
[0067] The steps of establishing a mouse model infected with Japanese encephalitis virus are the same as in Example 1, and the therapeutic effect of carfilzomib on mice infected with Japanese encephalitis virus is as follows:
[0068] 2. Evaluation of the therapeutic effect of carfilzomib on mice infected with Japanese encephalitis virus
[0069] 1. Experimental materials
[0070] (1) Drug: Carfilzomib, traits: white powder, method of use: use 2% DMSO+30% PEG 300+2% Tween 80+ddH 2 O is dissolved and administered intravenously.
[0074] Four-week-old Balb / c female mice were divided into four groups: PBS group (blank control gro...
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technical field [0001] The invention relates to the technical field of medicine, in particular to the use of a 20S proteasome inhibitor in the preparation of a medicine for treating Japanese encephalitis virus infection. Background technique [0002] Japanese encephalitis virus (Japanese encephalitis virus, JEV) belongs to FlaviviridaeFlavivirusgenus, is the pathogen that causes nervous system infectious disease - Japanese encephalitis, other members of the same genus are West Nile virus (West Nile virus) virus, WNV), yellow fever virus (Yellowfever virus, YFV), dengue virus (DENV) 1-4 types, Zika virus (Zika virus, ZIKV), etc. The virus is mainly transmitted through the bites of mosquitoes carrying the virus, and Culex tritaeniorhynchus is the main vector of the virus. Therefore, the prevalence of the virus shows obvious seasonality, with frequent occurrence in summer and autumn. [0003] Japanese encephalitis virus mainly infects pigs, horses, cattle and other animals a...
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