Rodent model of prostate cancer

A technology for rodents and prostates, applied in animal cells, vertebrate cells, microorganisms, etc., can solve problems such as limiting correlations
CN108135151AInactive Publication Date: 2018-06-08REGENERON PHARM INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
REGENERON PHARM INC
Publication Date
2018-06-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

This disclosure provides a rodent model of prostate cancer. The rodents disclosed herein comprise a transgene that provides prostate-specific expression of an oncogenic protein (e.g, an SV40 tumor antigen) under the control of 5' and 3' regulatory regions of a mouse probasin gene. The rodents develop progressive forms of prostate tumor that resemble the development of human prostate cancer.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of priority to US Provisional Application No. 62 / 213,389, filed September 2, 2015, the entire contents of which are incorporated herein by reference. field of invention

[0003] The present disclosure relates to a rodent model of prostate cancer. The rodents disclosed herein comprise a transgene comprising the SV40 tumor antigen coding sequence operably linked to the 5' and 3' regulatory regions of the mouse probasin gene. The rodents disclosed herein exhibit prostate-specific expression of the transgene and develop progressive forms of prostate tumors that mimic the development of human prostate cancer.

[0004] The sequence listing is incorporated by reference

[0005] The sequence listing is an ASCII text file named 32350_10161US01_SequenceListing.txt with a size of 440KB created on August 24, 2016, submitted to the US Patent and Trademark Office via EFS-Web, and incorporated here...

Claims

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