Application of metformin to preparation of medicine for preventing and/or treating opioid drug addiction, medicine and preparation method of medicine

A technology of metformin and opioids, which is applied in the field of medicine to achieve the effect of reducing economic burden, low price and high safety

Inactive Publication Date: 2018-06-15
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether metformin can prevent and / or treat opioid addiction has not been reported

Method used

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  • Application of metformin to preparation of medicine for preventing and/or treating opioid drug addiction, medicine and preparation method of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 2

[0022] Example 1 Metformin resists morphine-induced conditioned place preference experiment

[0023] 1. The experimental animals used are: SPF grade C57BL / 6 mice, male, 7-8 weeks old, weighing 23 g, provided by the Experimental Animal Center of Chongqing Medical University. Mice were housed in isolation in single cages, fed special feed, and had free access to food and water.

[0024]2. The drugs used are: Metformin (purchased from SIGMA-ALDRICH, Lot#LRAA8975, the United States), Morphine Hydrochloride Injection (Northeast Pharmaceutical Group Company Shenyang No. 1 Pharmaceutical Factory).

[0025] The preparation method of metformin (200 mg / Kg): 4.6 mg dissolved in 200 microliters of sterile water was administered orally to mice weighing 23 g.

[0026] The preparation method of morphine (20 mg / Kg): 46 microliters of 10 mg / ml morphine hydrochloride injection was dissolved in 54 microliters of normal saline, and intraperitoneal injection was administered to mice weighing 23 g...

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Abstract

The invention discloses an application of metformin to preparation of a medicine for preventing and / or treating the opioid drug addiction, the medicine and a preparation method of the medicine, and relates to the technical field of medicines. The metformin has the antagonistic effect on the position preference behavior caused by morphine and can be used to prevent and treat the opioid drug addiction, the application range of the metformin is further expanded, the technical bias is overcome, and the medicine has the advantages of remarkable treatment effect, high safety and low cost, does not cause addiction, has no side effects, relieves the financial burden of a patient, and is of great significance for the prevention and treatment of the opioid drug addiction.

Description

technical field [0001] The invention provides an application of metformin, in particular the application of metformin in the preparation of a drug for preventing and / or treating opioid drug addiction, and also relates to the drug and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Opioid abuse is one of the social hazards of the world today. Common opioids include morphine, heroin, and opium. Opioid drug addiction refers to the formation of mental and physical dependence after repeated use of opioid drugs, and severe withdrawal symptoms after drug withdrawal. It is a chronic recurrent brain disease. The treatment for opioid addiction is detoxification, which consists of three organically linked links: detoxification, relapse prevention, and social reintegration. Detoxification is the basis of detoxification treatment, specifically referring to the process of giving drug addicts drug treatment or controlling their detoxificati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/155A61P25/36
CPCA61K31/155
Inventor 白洁郭宁宁范伟张乐严晨李翔
Owner KUNMING UNIV OF SCI & TECH
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