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Application of metformin to preparation of medicine for preventing and/or treating benzedrine drug addiction, medicine and preparation method of medicine

A technology of metformin and amphetamines, which is applied in the field of medicine and achieves the effects of low price, no addiction and remarkable curative effect

Inactive Publication Date: 2018-06-15
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Whether metformin can prevent and / or treat amphetamine addiction has not been reported

Method used

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  • Application of metformin to preparation of medicine for preventing and/or treating benzedrine drug addiction, medicine and preparation method of medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 2

[0023] Example 1 Metformin resistance to metformin-induced conditioned place preference experiment

[0024] 1. The experimental animals used are: SPF C57BL / 6 mice, male, 7-8 weeks old, weighing 23 g, provided by the Experimental Animal Center of Chongqing Medical University. The mice are kept in isolation in a single cage, fed with special feed, and eat and drink freely.

[0025] 2. The drugs used are: Metformin (purchased from SIGMA-ALDRICH, Lot#LRAA8975, USA), and methamphetamine (provided by the Yunnan Provincial Public Security Bureau).

[0026] The preparation method of metformin (200 mg / Kg): Dissolve 4.6 mg in 200 microliters of sterile water, and gavage 23 g mice.

[0027] Methamphetamine (2.5 mg / Kg) preparation method: 0.344 mg tablets with a purity of 16.7%, dissolved in 100 microliters of normal saline, and administered by intraperitoneal injection to mice weighing 23 g.

[0028] Location preference behavior detection device: It is composed of two device boxes of the same siz...

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Abstract

The invention discloses an application of metformin to preparation of a medicine for preventing and / or treating benzedrine drug addiction, the medicine and a preparation method of the medicine, and relates to the technical field of medicines. The metformin has the antagonistic effect on the position preference behavior caused by morphine and can be used to prevent and treat the benzedrine drug addiction, the application range of the metformin is further expanded, the technical bias is overcome, and the medicine has the advantages of remarkable treatment effect, high safety and low cost, does not cause addiction, has no side effects, relieves the financial burden of a patient, and is of great significance for the prevention and treatment of the benzedrine drug addiction.

Description

Technical field [0001] The invention provides an application of metformin, in particular the application of metformin in the preparation of a drug for preventing and / or treating amphetamine addiction, and also relates to the drug and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Drug addiction is an international public hazard and a long-term worldwide problem. It has become one of the main enemies of mankind in the 21st century. There are many types of drugs. Among the newly discovered drug users, opioid abusers accounted for 17.4%, synthetic drug abusers accounted for 80.5%, and methamphetamine (METH) and other amphetamine abusers accounted for 73.2%. Therefore, The abuse of new drugs represented by methamphetamine is on the rise. [0003] The addictive symptoms of amphetamines are especially psychiatric, and withdrawal is very difficult, and there is no effective treatment at present. Research on drugs that can effectively, saf...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/155A61P25/36
CPCA61K31/155
Inventor 白洁黄梦兵张乐郭宁宁范伟严晨李晔
Owner KUNMING UNIV OF SCI & TECH
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