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Liquid flow control device used for microfluidic control and microfluidic control method

A technology for controlling device and liquid flow, which is applied to valve devices, lift valves, engine components, etc., can solve problems such as affecting droplet positioning and affecting accuracy, and achieves the effect of safe and reliable cost, no maintenance, and increased cost.

Active Publication Date: 2018-06-29
WUXI TMAXTREE BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, at the moment when the valve is closed, if the flow of the liquid cannot be immediately blocked, it will not only affect the accuracy of the volume of the liquid entering the chip, but also affect the positioning of the droplet and the control of the droplet during the manipulation of the droplet. Quantitative segmentation and fusion of

Method used

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  • Liquid flow control device used for microfluidic control and microfluidic control method
  • Liquid flow control device used for microfluidic control and microfluidic control method
  • Liquid flow control device used for microfluidic control and microfluidic control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] In one embodiment, a liquid flow control device for micro-flow control includes a hollow body 1 and a movable piston 2 disposed in the body 1, the body 1 includes a liquid inlet 3 and a liquid outlet 4, The liquid inlet 3, the movable piston 2 and the liquid outlet 4 form a liquid chamber with a variable volume. The liquid inlet channel from the liquid port 3 to the junction of the piston 2 and the partition wall, and the liquid outlet passage from the junction of the piston 2 and the partition wall to the liquid outlet 4, the liquid outlet passage includes a capillary 6 and is filled in the capillary 6 and the liquid outlet The filling between the channels, when the piston 2 is in the open position, the liquid flows through the liquid inlet channel from the liquid inlet 3 and / or the liquid flows through the liquid outlet channel and is discharged from the liquid outlet 4, when the piston 2 is in the closed position, The piston 2 closes the capillary 6 so that the resis...

Embodiment 2

[0047] In one embodiment of the present invention, the volume of the capillary, that is, the liquid outlet channel is smaller than the volume of the liquid inlet channel, wherein the cross-sectional size of the liquid outlet channel is smaller than or equal to the cross-sectional size of the liquid inlet channel. The volume of the liquid outlet channel is smaller than the volume of the liquid inlet channel so that when the piston is closed, the resistance of the liquid entering the chip is greater than the resistance of the liquid returning to the liquid inlet channel, and the liquid enters the liquid inlet channel more easily than the liquid outlet channel. There are many ways that the volume of the liquid channel is smaller than the volume of the liquid inlet channel, for example, the cross-sectional size of the liquid outlet channel is smaller than the cross-sectional size of the liquid inlet channel.

[0048] In one embodiment of the present invention, the cross-sectional s...

Embodiment 3

[0051] A liquid flow control device for micro-flow control comprises a hollow main body 1 and a movable piston 2 arranged in the main body 1, the main body 1 includes a liquid inlet 3 and a liquid outlet 4, the liquid inlet 3 , the movable piston 2 and the liquid outlet 4 form a variable-volume liquid chamber, the liquid chamber is provided with a partition wall 5, and the liquid chamber is divided into a liquid chamber from the liquid inlet 3 to the piston 2 via the partition wall 5. The liquid inlet passage at the junction of the partition wall and the liquid outlet passage from the junction of the piston 2 and the partition wall to the liquid outlet 4, the liquid outlet passage includes a capillary 6 and a filler filled between the capillary 6 and the liquid outlet passage, When the piston 2 is in the open position, the liquid flows from the liquid inlet 3 through the liquid inlet channel and the liquid outlet channel to be discharged from the liquid outlet 4, and the capill...

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PUM

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Abstract

The invention relates to a liquid flow control device used for microfluidic control and a microfluidic control method. The device comprises a hollow main body (1) and a movable piston (2) arranged inthe main body (1); the main body (1) comprises a liquid inlet (3) and a liquid outlet (4), and a liquid cavity with the changeable volume is formed by the liquid inlet (3), the movable piston (2) andthe liquid outlet (4), the liquid cavity is provided with a partition wall (5), the liquid cavity is divided into a liquid inlet channel and the liquid outlet channel through the partition wall (5), the liquid inlet channel is from the liquid inlet (3) to the combining position between the piston (2) and the partition wall, and the liquid outlet channel is from the combining position of the piston(2) and the partition wall and the liquid outlet (4), the liquid outlet channel comprises a capillary tube (6) and a filler arranged between the capillary tube (6) and the liquid outlet channel in afilling manner, the piston (2) is located at the opening position, liquid flows through the liquid inlet channel and / or flows through the liquid outlet channel form the liquid inlet (3) and is drainedfrom the liquid outlet (4), the piston (2) is located at the closing position, the piston (2) closes the capillary tube (6) so as to enable resistance of liquid entering the liquid outlet channel tobe larger than resistance of the liquid entering the liquid inlet channel so as to prevent remaining microfluidic drops from flowing out of the liquid outlet (4).

Description

technical field [0001] The invention relates to the field of microfluidic control, in particular to a liquid flow control device and a microfluidic control method for microfluidic control. Background technique [0002] With the rapid development of microfluidic chip technology, more and more attention has been paid to the switch control of microfluidic channels, especially for more precise requirements for liquid flow control. Microfluidic chips have micro-upgraded accuracy requirements for the inflowing liquid flow, but current liquid flow control devices are difficult to meet the accuracy requirements. Valves are often used in the field of microfluidics to control the opening or stopping of liquid flow. However, the size of the microfluidic chip pipeline is usually very small, usually on the micron or millimeter level, and the flow of liquid needs to be precisely controlled. Therefore, at the moment when the valve is closed, if the flow of the liquid cannot be immediatel...

Claims

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Application Information

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IPC IPC(8): F16K1/00
Inventor 王立言蒙玄
Owner WUXI TMAXTREE BIOTECHNOLOGY CO LTD